Monoglyerides (MGs) are short-lived, intermediary lipids deriving from the degradation of
phospho-and neutral lipids, and monoglyceride lipase (MGL), also designated as …

Monoacylglycerol lipase (MAGL) is a key enzyme responsible for the termination of
endocannabinoid signaling. Its crucial role in 2‐arachidonoylglycerol (2‐AG) metabolism …

Monoacylglycerol lipase (MAGL) has been characterized as the main enzyme responsible
for the inactivation of the most abundant brain endocannabinoid, 2-arachidonoylglycerol (2 …

Together with anandamide, 2-arachidonoylglycerol (2-AG) constitutes one of the main
representatives of a family of endogenous lipids known as endocannabinoids. These act by …

Monoacylglycerol lipase (MAGL) is a principal degradative enzyme for the endocannabinoid
2-arachidonoylglycerol (2-AG). We recently reported a piperidine carbamate, JZL184, that …

Monoacylglycerol lipase (MAGL) is the main enzyme responsible for degradation of the
endocannabinoid 2-arachidonoylglycerol (2-AG) in the CNS. MAGL catalyzes the …

Monoglyceride lipase (MGL) plays a major role in the metabolism of the lipid transmitter 2‐
arachidonoylglycerol (2‐AG). This endocannabinoid is known to mediate a large number of …

Monoacylglycerol lipase (MAGL) has been recently proposed as the main enzymatic activity
responsible for the in vivo hydrolysis of the most abundant endocannabinoid in the brain, the …

Marijuana and aspirin have been used for millennia to treat a wide range of maladies
including pain and inflammation. Both cannabinoids, like marijuana, that exert anti …

Highlights•2-Arachidonoylglycerol (2-AG) is at the crossroads of the endocannabinoid and
the eicosanoid systems.•Pharmacological tools are available to control 2-AG levels in …