Background Vancomycin is a commonly prescribed antibiotic to treat serious Gram-positive
infections in children. The efficacy of vancomycin is known to be directly related to the …

Background Vancomycin is a commonly prescribed antibiotic to treat gram-positive
infections. The efficacy of vancomycin is known to be directly related to the pharmacokinetic …

Background Model-informed precision dosing (MIPD) can serve as a powerful tool during
therapeutic drug monitoring (TDM) to help individualize dosing in populations with large …

Pharmacokinetic modeling has often been applied to evaluate vancomycin
pharmacokinetics in neonates. However, clinical application of the model-based …

Background Vancomycin is commonly used for treatment of severe Gram+ neonatal
infections. Currently, even with the use of optimized dosing regimens and therapeutic drug …

We recruited 48 neonates (50 vancomycin treatment episodes) in a prospective study to
validate a model-informed precision dosing (MIPD) software. The initial vancomycin dose …

Abstract Background The Dutch Pediatric Formulary (DPF) increasingly bases its guidelines
on model-based dosing simulations from pharmacokinetic studies. This resulted in …

Vancomycin is a glycopeptide antibiotic that has been adopted in clinical practice to treat
gram-positive infections for more than 70 years. Despite vancomycin's long history of …

Introduction Few studies incorporating population pharmacokinetic/pharmacodynamic (Pop-
PK/PD) modelling have been conducted to quantify the exposure target of vancomycin in …

Area under the curve (AUC)-directed vancomycin therapy is recommended, but Bayesian
AUC estimation in critically ill children is difficult due to inadequate methods for estimating …