Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

BM Wolpin, C Rizzato, P Kraft, C Kooperberg… - Nature …, 2014 - nature.com
We performed a multistage genome-wide association study including 7,683 individuals with
pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome …

A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22. 1, 1q32. 1 and 5p15. 33

GM Petersen, L Amundadottir, CS Fuchs, P Kraft… - Nature …, 2010 - nature.com
We conducted a genome-wide association study of pancreatic cancer in 3,851 affected
individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies …

Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations

C Wu, X Miao, L Huang, X Che, G Jiang, D Yu… - Nature …, 2012 - nature.com
Pancreatic cancer has the lowest survival rate among human cancers, and there are no
effective markers for its screening and early diagnosis. To identify genetic susceptibility …

Common variation at 2p13. 3, 3q29, 7p13 and 17q25. 1 associated with susceptibility to pancreatic cancer

EJ Childs, E Mocci, D Campa, PM Bracci, S Gallinger… - Nature …, 2015 - nature.com
Pancreatic cancer is the fourth leading cause of cancer death in the developed world. Both
inherited high-penetrance mutations in BRCA2 (ref.), ATM, PALB2 (ref.), BRCA1 (ref.) …

A transcriptome-wide association study identifies novel candidate susceptibility genes for pancreatic cancer

J Zhong, A Jermusyk, L Wu, JW Hoskins… - JNCI: Journal of the …, 2020 - academic.oup.com
Background Although 20 pancreatic cancer susceptibility loci have been identified through
genome-wide association studies in individuals of European ancestry, much of its heritability …

[HTML][HTML] Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32. 1, 5p15. 33 and 8q24. 21

M Zhang, Z Wang, O Obazee, J Jia, EJ Childs… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Genome-wide association studies (GWAS) have identified common pancreatic cancer
susceptibility variants at 13 chromosomal loci in individuals of European descent. To identify …

[HTML][HTML] Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

AP Klein, BM Wolpin, HA Risch… - Nature …, 2018 - nature.com
Abstract In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe
and the United States combined. To identify common susceptibility alleles, we performed the …

[HTML][HTML] A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34

MA Eberle, R Pfützer, KL Pogue-Geile… - The American Journal of …, 2002 - cell.com
Pancreatic cancer is the fifth leading cause of cancer death in the United States. Nearly
every person diagnosed with pancreatic cancer will die from it, usually in< 6 mo. Familial …

Whole genome sequencing defines the genetic heterogeneity of familial pancreatic cancer

NJ Roberts, AL Norris, GM Petersen, ML Bondy… - Cancer discovery, 2016 - AACR
Pancreatic cancer is projected to become the second leading cause of cancer-related death
in the United States by 2020. A familial aggregation of pancreatic cancer has been …

Pancreatic cancer genetic epidemiology consortium

GM Petersen, M De Andrade, M Goggins… - … Biomarkers & Prevention, 2006 - AACR
We have organized the Pancreatic Cancer Genetic Epidemiology (PACGENE) Consortium
to identify susceptibility genes in familial pancreatic cancer (FPC). The Consortium …