Human resident memory T cells exit the skin and mediate systemic Th2-driven inflammation

J Strobl, LM Gail, L Kleissl, RV Pandey… - Journal of Experimental …, 2021 - rupress.org
Emigration of tissue-resident memory T cells (TRMs) was recently introduced in mouse
models and may drive systemic inflammation. Skin TRMs of patients undergoing allogeneic …

Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease

J Strobl, RV Pandey, T Krausgruber, N Bayer… - Science translational …, 2020 - science.org
The skin contains a population of tissue-resident memory T cells (Trm) that is thought to
contribute to local tissue homeostasis and protection against environmental injuries …

Human skin-resident host T cells can persist long term after allogeneic stem cell transplantation and maintain recirculation potential

GP de Almeida, P Lichtner, G Eckstein… - Science …, 2022 - science.org
Tissue-resident memory T cells (TRM) have recently emerged as crucial cellular players for
host defense in a wide variety of tissues and barrier sites. Insights into the maintenance and …

Human CD4+CD103+ cutaneous resident memory T cells are found in the circulation of healthy individuals

MM Klicznik, PA Morawski, B Höllbacher… - Science …, 2019 - science.org
Tissue-resident memory T cells (TRM) persist locally in nonlymphoid tissues where they
provide frontline defense against recurring insults. TRM at barrier surfaces express the …

[HTML][HTML] Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites

BV Kumar, W Ma, M Miron, T Granot, RS Guyer… - Cell reports, 2017 - cell.com
Tissue-resident memory T cells (TRMs) in mice mediate optimal protective immunity to
infection and vaccination, while in humans, the existence and properties of TRMs remain …

Tissue-resident memory T cells and their biological characteristics in the recurrence of inflammatory skin disorders

L Chen, Z Shen - Cellular & molecular immunology, 2020 - nature.com
The skin is the largest organ of the body. The establishment of immunological memory in the
skin is a crucial component of the adaptive immune response. Once naive T cells are …

Tissue-specific differentiation of CD8+ resident memory T cells

K Yang, A Kallies - Trends in Immunology, 2021 - cell.com
CD8+ tissue-resident memory T (T RM) cells play crucial roles in defense against infections
and cancer and have been implicated in autoimmune diseases such as psoriasis. In mice …

[HTML][HTML] Functional heterogeneity of human tissue-resident memory T cells based on dye efflux capacities

BV Kumar, R Kratchmarov, M Miron, DJ Carpenter… - JCI insight, 2018 - ncbi.nlm.nih.gov
Tissue-resident memory T cells (TRMs) accelerate pathogen clearance through rapid and
enhanced functional responses in situ. TRMs are prevalent in diverse anatomic sites …

[HTML][HTML] Tissue–Resident Memory T Cells in Chronic Inflammation—Local Cells with Systemic Effects?

AAK Samat, J van der Geest, SJ Vastert… - Cells, 2021 - mdpi.com
Chronic inflammatory diseases such as rheumatoid arthritis (RA), Juvenile Idiopathic
Arthritis (JIA), psoriasis, and inflammatory bowel disease (IBD) are characterized by …

The evolving role of tissue-resident memory T cells in infections and cancer

S Yenyuwadee, JL Sanchez-Trincado Lopez… - Science …, 2022 - science.org
Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in
tissues. TRM form an integral part of the immune sensing network and have the ability to …