Cancer immunotherapy has been established as standard of care in different tumor entities.
After the first reports on synergistic effects with radiotherapy and the induction of abscopal …

Tumor tissue includes cancer cells and normal stromal cells such as vascular endothelial
cells, connective tissue cells (cancer associated fibroblast, mesenchymal stem cell), and …

Purpose: Radioresistance of cancer cells remains a fundamental barrier for maximum
efficient radiotherapy. Tumor heterogeneity and the existence of distinct cell subpopulations …

Chemokines, which have chemotactic abilities, are comprised of a family of small cytokines
with 8-10 kilodaltons. Chemokines work in immune cells by trafficking and regulating cell …

CXCR3 is a chemokine receptor with three ligands; CXCL9, CXCL10, and CXCL11.
CXCL11 binds CXCR3 with a higher affinity than the other ligands leading to receptor …

Signaling involving chemokine receptor CXCR4 and its ligand SDF-1/CXL12 has been
investigated for many years for its possible role in cancer progression and pathogenesis …

Review discusses the role of CXCL12 (SDF1α) as a regulatory chemokine that drives Foxp3-
regulatory T cells (Tr1), and its therapeutic implications. Chemokines are a group of small …

Simple Summary Chemokines are small soluble proteins that control and regulate cell
trafficking within and between tissues by binding to their receptors. Among them, CXCL12 …

The G protein–coupled protein receptor CXC chemokine receptor 4 (CXCR4) is an attractive
target for cancer diagnosis and treatment, as it is overexpressed in many solid and …

Background Increasing infiltration of CD8+ T cells within tumor tissue predicts a better
prognosis and is essential for response to checkpoint blocking therapy. Furthermore, current …