Infertility is an often devastating diagnosis encountered by around one in six couples who
are trying to conceive. Moving away from the long-held belief that infertility is primarily a …

Sperm undergo some of the most extensive chromatin modifications seen in mammalian
biology. During male germline development, paternal DNA methylation marks are erased …

Although male infertility is currently diagnosed when abnormal sperm parameters are found,
the poor predictive ability of sperm parameters on natural fecundity and medically assisted …

Along with many of the genome-wide transitions in chromatin composition throughout
spermatogenesis, epigenetic modifications on histone tails and DNA are continuously …

Recent work in the field of male fertility has yielded significant increases in our
understanding of the sperm epigenome and its potential role in embryonic development …

The mammalian sperm contains a highly unique and specialized epigenetic landscape that
offers a great degree of interesting research opportunities. One key discriminating feature of …

The molecular basis of male infertility is poorly understood, the majority of cases remaining
unsolved. The association of aberrant sperm DNA methylation patterns and compromised …

Infertility is a complex disorder with multiple genetic and environmental causes. Although
some specific mutations have been identified, other factors responsible for sperm defects …

STUDY QUESTION Is there a distinct sperm histone-retained epigenetic signature in
unexplained male factor infertility patients resulting in compromised blastocyst …

An understanding of the epigenetic mechanisms involved in sperm production and their
impact on the differentiating embryo is essential if we are to optimize fertilization and …