Efficiency of cell-type specific and generic promoters in transducing oxytocin neurons and monitoring their neural activity during lactation

K Thirtamara Rajamani, AB Leithead, M Kim… - Scientific Reports, 2021 - nature.com
Hypothalamic oxytocin (OXT) and arginine-vasopressin (AVP) neurons have been at the
center of several physiological and behavioral studies. Advances in viral vector biology and …

[HTML][HTML] Recording and manipulation of the maternal oxytocin neural activities in mice

H Yukinaga, M Hagihara, K Tsujimoto, HL Chiang… - Current Biology, 2022 - cell.com
Pulsatile release of the hormone oxytocin (OT) mediates uterine contraction during
parturition and milk ejection during lactation. 1–3 These pulses are generated by the unique …

Identification of peripheral oxytocin‐expressing cells using systemically applied cell‐type specific adeno‐associated viral vector

L Paiva, M Lozic, A Allchorne… - Journal of …, 2021 - Wiley Online Library
Oxytocin is primarily synthesised in the brain and is widely known for its role in lactation and
parturition after being released into the blood from the posterior pituitary gland …

Whole-brain wiring diagram of oxytocin system in adult mice

S Son, SB Manjila, KT Newmaster, Y Wu… - Journal of …, 2022 - Soc Neuroscience
Oxytocin (Oxt) neurons regulate diverse physiological responses via direct connections with
different neural circuits. However, the lack of comprehensive input-output wiring diagrams of …

Bovine Oxytocin Transgenes in Mice: Hypothalamic Expression, Physiological Regulation, and Interactions with the Vasopressin Gene

MY Ho, DA Carter, HL Ang, D Murphy - Journal of Biological Chemistry, 1995 - ASBMB
To gain insights into the molecular mechanisms that restrict the expression of the oxytocin
gene to anatomically defined groups of neurons in the hypothalamus, we generated …

Evidence for a hypothalamic oxytocin-sensitive pattern-generating network governing oxytocin neurons in vitro

P Jourdain, JM Israel, B Dupouy, SHR Oliet… - Journal of …, 1998 - Soc Neuroscience
During lactation and parturition, magnocellular oxytocin (OT) neurons display a
characteristic bursting electrical activity responsible for pulsatile OT release. We investigated …

Advanced genetic and viral methods for labelling and manipulation of oxytocin and vasopressin neurones in rats

M Yoshimura, Y Ueta - Cell and tissue research, 2019 - Springer
Rats have been widely used as one of the most common laboratory animals for biological
research, because their physiology, pathology, and behavioral characteristics are highly …

Cell-type specific oxytocin gene expression from AAV delivered promoter deletion constructs into the rat supraoptic nucleus in vivo

RL Fields, TA Ponzio, M Kawasaki, H Gainer - PloS one, 2012 - journals.plos.org
The magnocellular neurons (MCNs) in the hypothalamus selectively express either oxytocin
(OXT) or vasopressin (AVP) neuropeptide genes, a property that defines their phenotypes …

Oxytocin via oxytocin receptor excites neurons in the endopiriform nucleus of juvenile mice

LM Biggs, EAD Hammock - Scientific Reports, 2022 - nature.com
The neuropeptide oxytocin (OXT) modulates social behaviors across species and may play
a developmental role for these behaviors and their mediating neural pathways. Despite …

Mapping oxytocin receptor gene expression in the mouse brain and mammary gland using an oxytocin receptor–LacZ reporter mouse

BR Gould, HH Zingg - Neuroscience, 2003 - Elsevier
The hypothalamic nonapeptide oxytocin (OT) has an established role as a circulating
hormone but can also act as a neurotransmitter and as a neuromodulator by interacting with …