Background: Caspases (CASPs) are the main executors of the apoptotic process. Studies to
date have shown the role of caspase-8 (CASP8) and caspase-9 (CASP9) in carcinogenesis …

Abstract Caspase-8 (CASP8) is one key regulator of apoptosis of T lymphocytes and is
encoded by the CASP8 gene. It has been reported that the six-nucleotide deletion …

Disruptions of normal apoptotic pathways, which are mainly mediated by caspases, play an
essential role in cancer development. Caspase-8 (CASP8) is encoded by the CASP8 gene …

Genetic variations in the caspase genes CASP-3 and CASP-7 are known to be involved in
apoptosis, cytokine maturation, cell growth and differentiation. Polymorphisms of CASP-3 …

Abstract Background and purpose: Non-Hodgkin lymphomas are closely related diseases
with distinctive morphologic, immunophenotypic, genetic, and clinical features. Genetic …

Caspase-8 (encoded by the CASP-8 gene) is crucial in generating cell death signals and
eliminating potentially malignant cells. Genetic variation in CASP8 may affect susceptibility …

Objectives Apoptosis is defined as programmed cell death, which regulates cellular
functions and various physiological responses. Several studies reported that Caspase …

Abstract Caspase-8 (CASP8), member of the caspase cysteine protease family, plays an
important role in cancer development. CASP8 D302H (rs1045485)(D, Aspartate; H …

Caspase-8 plays is an essential enzyme in apoptosis pathway. Several investigation have
been done to identify the relation between CASP8 polymorphisms and different human …

Abstract Caspase-9 (CASP9) and caspase-10 (CASP10) polymorphisms were associated
with human cancers; however, the results remain controversial. In this meta-analysis, we …