Epigenetics has long been recognized as a significant field in biology and is defined as the
investigation of any alteration in gene expression patterns that is not attributed to changes in …

Epigenetic changes such as DNA methylation and histone methylation and acetylation alter
gene expression at the level of transcription by upregulating, downregulating, or silencing …

Cancer has traditionally been hailed a genetic disease, dictated by successive genetic
aberrations which alter gene expression. Yet, recent advances in molecular sequencing …

Epigenetic gene silencing is a hallmark of cancer cells. Two important types of epigenetic
changes are DNA methylation and histone modification. These modifications are catalysed …

Epigenetic changes are defined as inherited modifications that are not present in DNA
sequence. Gene expression is regulated at various levels and not only in response to DNA …

In addition to the genetic alterations, observed in cancer cells, are mitotically heritable
changes in gene expression not encoded by the DNA sequences, which are referred to as …

Over the past few years several drugs that target epigenetic modifications have shown
clinical benefits, thus seemingly validating epigenetic cancer therapy. More recently …

Epigenetics refers to heritable changes in gene expression and chromatin structure without
change in a DNA sequence. Several epigenetic modifications and respective regulators …

Epigenetics play a crucial role in gene regulation and cellular processes. Most importantly,
its dysregulation can contribute to the development of tumors. Epigenetic modifications, such …

Epigenetics now refers to the study or research field related to DNA methylation and histone
modifications. Historically, global DNA hypomethylation was first revealed in 1983, and, after …