The dorsal horn (DH) of the spinal cord receives a variety of sensory information arising from
the inner and outer environment, as well as modulatory inputs from supraspinal centers. This …

Neurons in the spinal dorsal horn process sensory information, which is then transmitted to
several brain regions, including those responsible for pain perception. The dorsal horn …

Noxious stimuli can usually cause the aversive sensations, pain and itch. The initial
integration of such noxious information occurs in the superficial dorsal horn of the spinal …

Numerous systems within the central nervous system can act to increase or decrease
incoming pain messages. Endogenous descending inhibitory and facilitatory control …

It has become increasingly clear that nociceptive information is signalled by several
anatomically distinct populations of primary afferents that target different populations of …

A review of the literature on pain-signalling systems in the spinal cord provides convincing
evidence that nociceptive information is transmitted by multiple ascending systems. These …

The spinal dorsal horn (DH) processes sensory information and plays a key role in
transmitting nociception to supraspinal centers. Loss of DH inhibition during neuropathic …

Maladaptive plasticity within the dorsal horn (DH) of the spinal cord is a key substrate for
development of neuropathic pain following peripheral nerve injury. Advances in genetic …

Non‐technical summary The dorsal horn of the spinal cord is the first site in the central
nervous system where painful sensory information is processed before transmission to the …

All higher organisms possess a sensory system that allows them to detect potentially tissue-
damaging (or noxious) stimuli. The proper functioning of this system is essential to protect …