Rationale: Current therapies for obstructive sleep apnea (OSA) are limited by insufficient
efficacy, compliance, or tolerability. An effective pharmacological treatment for OSA is …

Introduction Obstructive sleep apnea (OSA) is a common and serious breathing disorder.
Several pathophysiological factors predispose individuals to OSA. These factors are …

Rationale: Primary treatment of obstructive sleep apnea can be accompanied by a
persistence of excessive sleepiness despite adherence. Furthermore, effectiveness of sleep …

Rationale: The combination of noradrenergic and antimuscarinic agents has recently been
shown to improve upper-airway function and reduce obstructive sleep apnea (OSA) severity …

Background Solriamfetol, a dopamine-norepinephrine reuptake inhibitor, is approved in the
United States to improve wakefulness in adults with excessive daytime sleepiness (EDS) …

Rationale: There is currently no effective pharmacological treatment for obstructive sleep
apnea (OSA). Recent investigations indicate that drugs with noradrenergic and …

Carbonic anhydrase inhibition reduces apnoeic events in sleep disordered breathing.
Zonisamide inhibits carbonic anhydrase, and induces weight loss in obese patients. This …

Current forms of mechanical treatment in obstructive sleep apnea (OSA) are generally
effective in eliminating sleep and breathing disorders. However, they do have drawbacks …

Rationale: Obstructive sleep apnea (OSA) is a common sleep disorder for which the
principal treatment option, continuous positive airway pressure, is often poorly tolerated …

Study Objective: Obstructive sleep apnea is a common and serious sleep disorder for which
treatment remains challenging due to lack of adherence to approved therapies. Previous …