Tuberculosis vaccine development: from classic to clinical candidates

J Li, A Zhao, J Tang, G Wang, Y Shi, L Zhan… - European Journal of …, 2020 - Springer
Abstract Bacillus Calmette-Guérin (BCG) has been in use for nearly 100 years and is the
only licensed TB vaccine. While BCG provides protection against disseminated TB in infants …

An overview of the development of new vaccines for tuberculosis

E Whitlow, AS Mustafa, SNM Hanif - Vaccines, 2020 - mdpi.com
Currently, there is only one licensed vaccine against tuberculosis (TB), the Bacillus Calmette–
Guérin (BCG). Despite its protective efficacy against TB in children, BCG has failed to protect …

Tuberculosis vaccine: A journey from BCG to present

S Fatima, A Kumari, G Das, VP Dwivedi - Life sciences, 2020 - Elsevier
Tuberculosis (TB) is the leading cause of death worldwide due to an infectious disease,
causing around 1.6 million deaths each year. This situation has become more complicated …

Tuberculosis vaccine development: progress in clinical evaluation

SB Sable, JE Posey, TJ Scriba - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Tuberculosis (TB) is the leading killer among all infectious diseases worldwide despite
extensive use of the Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine. A safer …

Novel vaccination strategies against tuberculosis

P Andersen, SHE Kaufmann - Cold Spring …, 2014 - perspectivesinmedicine.cshlp.org
The tuberculosis (TB) pandemic continues to rampage despite widespread use of the BCG
(Bacillus Calmette–Guérin) vaccine. Novel vaccination strategies are urgently needed to …

Development of tuberculosis vaccines in clinical trials: Current status

P Méndez‐Samperio - Scandinavian journal of immunology, 2018 - Wiley Online Library
Tuberculosis (TB) is an important infectious disease worldwide. Currently, Bacillus Calmette‐
Guérin (BCG) remains the only TB vaccine licensed for human use. This TB vaccine is …

Critical research concepts in tuberculosis vaccine development

G Delogu, R Manganelli… - Clinical Microbiology and …, 2014 - Wiley Online Library
A new and improved vaccine against tuberculosis (TB) would provide a powerful tool to
conquer one of the most insidious infectious diseases of mankind. Protection afforded by …

Tuberculosis vaccines in clinical trials

R Rowland, H McShane - Expert review of vaccines, 2011 - Taylor & Francis
Effective prophylactic and/or therapeutic vaccination is a key strategy for controlling the
global TB epidemic. The partial effectiveness of the existing TB vaccine, bacille Calmette …

The present and future of tuberculosis vaccinations

N Principi, S Esposito - Tuberculosis, 2015 - Elsevier
The clinical, social, and economic burden of tuberculosis (TB) remains high worldwide,
thereby highlighting the importance of TB prevention. The bacilli Calmette-Guérin (BCG) …

Vaccines against tuberculosis: where are we and where do we need to go?

THM Ottenhoff, SHE Kaufmann - PLoS pathogens, 2012 - journals.plos.org
In this review we discuss recent progress in the development, testing, and clinical evaluation
of new vaccines against tuberculosis (TB). Over the last 20 years, tremendous progress has …