The nephropathy of sickle cell trait and sickle cell disease

KI Ataga, SL Saraf, VK Derebail - Nature Reviews Nephrology, 2022 - nature.com
Sickle cell syndromes, including sickle cell disease (SCD) and sickle cell trait, are
associated with multiple kidney abnormalities. Young patients with SCD have elevated …

Sickle cell nephropathy: an update on pathophysiology, diagnosis, and treatment

E Hariri, A Mansour, A El Alam, Y Daaboul… - … Urology and Nephrology, 2018 - Springer
Sickle cell nephropathy is a major complication of sickle cell disease. It manifests in different
forms, including glomerulopathy, proteinuria, hematuria, and tubular defects, and frequently …

Sickle cell disease and the kidney

JI Scheinman - Nature clinical practice Nephrology, 2009 - nature.com
The renal features of sickle cell disease (SCD) include some of the most common reasons
for referral to nephrologists, such as hematuria, proteinuria, tubular disturbances and …

The glomerulopathy of sickle cell disease

KI Ataga, VK Derebail, DR Archer - American journal of …, 2014 - Wiley Online Library
Sickle cell disease (SCD) produces many structural and functional abnormalities in the
kidney, including glomerular abnormalities. Albuminuria is the most common manifestation …

Sickle cell nephropathy–a practical approach

CC Sharpe, SL Thein - British journal of haematology, 2011 - Wiley Online Library
Despite its apparently simple molecular aetiology, sickle cell disease (SCD) has long been
known to have a remarkably variable clinical course, with complications involving many …

New insights on pathophysiology, clinical manifestations, diagnosis, and treatment of sickle cell nephropathy

GB da Silva Junior, AB Libório… - Annals of …, 2011 - Springer
Sickle cell nephropathy is one of the main chronic complications of sickle cell disease
(SCD), the most common of the hematological hereditary disorders. Several studies have …

Sickle cell disease: renal manifestations and mechanisms

KA Nath, RP Hebbel - Nature Reviews Nephrology, 2015 - nature.com
Sickle cell disease (SCD) substantially alters renal structure and function, and causes
various renal syndromes and diseases. Such diverse renal outcomes reflect the uniquely …

[HTML][HTML] Renal abnormalities in sickle cell disease

PTT Pham, PCT Pham, AH Wilkinson, SQ Lew - Kidney international, 2000 - Elsevier
Renal abnormalities in sickle cell disease. Sickle cell nephropathy is indicated by sickled
erythrocytes, with the consequent effects of decreased medullary blood flow, ischemia …

The spectrum of sickle hemoglobin-related nephropathy: from sickle cell disease to sickle trait

RP Naik, VK Derebail - Expert review of hematology, 2017 - Taylor & Francis
Introduction: Renal dysfunction is among the most common complication of sickle cell
disease (SCD), from hyposthenuria in children to progression to overt chronic kidney …

Sickle cell nephropathy: challenging the conventional wisdom

AM Becker - Pediatric nephrology, 2011 - Springer
This review explores the current model of sickle cell nephropathy and the limitations of the
model. Renal abnormalities are common complications of sickle cell disease (SCD) …