Alginate oligosaccharide alleviates D‐galactose‐induced cardiac ageing via regulating myocardial mitochondria function and integrity in mice

W Feng, J Liu, S Wang, Y Hu, H Pan… - Journal of Cellular …, 2021 - Wiley Online Library
Ageing is a crucial risk factor for the development of age‐related cardiovascular diseases.
Therefore, the molecular mechanisms of ageing and novel anti‐ageing interventions need to …

Aging induced by D-galactose aggravates cardiac dysfunction via exacerbating mitochondrial dysfunction in obese insulin-resistant rats

C Bo-Htay, T Shwe, L Higgins, S Palee… - Geroscience, 2020 - Springer
The prevalence of obesity and an aging population are increasing worldwide. Both obesity
and aging are independently known to be associated with cardiac dysfunction. However, in …

Effects of d‐galactose‐induced ageing on the heart and its potential interventions

C Bo‐Htay, S Palee, N Apaijai… - Journal of Cellular …, 2018 - Wiley Online Library
Ageing is a strong independent risk factor for disability, morbidity and mortality. Post‐mitotic
cells including those in the heart are a particular risk to age‐related deterioration. As the …

D‐galactose‐induced cardiac ageing: A review of model establishment and potential interventions

S Wang, X Zhang, Z Ke, X Wen, W Li… - Journal of Cellular …, 2022 - Wiley Online Library
Cardiovascular disease (CVD) is highly prevalent in an ageing society. The increased
incidence and mortality rates of CVD are global issues endangering human health. There is …

Mitochondrial biogenesis and apoptosis as underlying mechanisms involved in the cardioprotective effects of Gallic acid against D-galactose-induced aging

M Zarei, A Sarihi, A Zamani, S Raoufi, SA Karimi… - Molecular Biology …, 2023 - Springer
Background Aging is a main risk factor for the development of cardiovascular diseases
(CVDs). Gallic acid (GA) is a phenolic compound derived from a wide range of fruits. GA has …

[HTML][HTML] Alginate oligosaccharide ameliorates D-galactose-induced kidney aging in mice through activation of the Nrf2 signaling pathway

H Pan, W Feng, M Chen, H Luan, Y Hu… - BioMed research …, 2021 - hindawi.com
Aging is an independent risk factor for the development of age-related progressive kidney
injury. As a part of the aging process, kidney aging has been indicated to be associated with …

[HTML][HTML] Ginkgo biloba extract EGB761 protects against aging-associated diastolic dysfunction in cardiomyocytes of D-galactose-induced aging rat

J Liu, J Wang, X Chen, C Guo, Y Guo… - Oxidative medicine and …, 2012 - hindawi.com
The aim of the present study was to make use of the artificially induced aging model
cardiomyocytes to further investigate potential anti-aging-associated cellular diastolic …

Alginate oligosaccharide alleviates myocardial reperfusion injury by inhibiting nitrative and oxidative stress and endoplasmic reticulum stress-mediated apoptosis

JJ Guo, FQ Xu, YH Li, J Li, X Liu, XF Wang… - Drug Design …, 2017 - Taylor & Francis
Alginate oligosaccharide (AOS) has recently demonstrated the ability to protect against
acute doxorubicin cardiotoxicity and neurodegenerative disorders by inhibiting oxidative …

[HTML][HTML] Thymoquinone and curcumin defeat aging-associated oxidative alterations induced by D-galactose in rats' brain and heart

AH El-Far, YHA Elewa, EZA Abdelfattah… - International Journal of …, 2021 - mdpi.com
D-galactose (D-gal) administration causes oxidative disorder and is widely utilized in aging
animal models. Therefore, we subcutaneously injected D-gal at 200 mg/kg BW dose to …

[HTML][HTML] Inhibition of Cardiac Hypertrophy Effects in D-Galactose-Induced Senescent Hearts by Alpinate Oxyphyllae Fructus Treatment

YM Chang, HH Chang, HJ Lin, CC Tsai… - Evidence-Based …, 2017 - hindawi.com
Aging is a complex physiological phenomenon accelerated by ROS accumulation, with
multisystem decline and increasing vulnerability to degenerative diseases and death …