Understanding the pathophysiology of atherogenesis and the progression of atherosclerosis
have been major goals of cardiovascular research during the previous decades. However …

Atherosclerotic cardiovascular disease remains the leading cause of death in the
industrialized world. Most cardiovascular deaths result from acute coronary syndromes …

Although the understanding of the underlying pathology of atherosclerosis has improved in
recent years, the disease is still the main cause of death globally. Current evidence has …

During atherosclerosis, lipid-rich plaques are formed in large-and medium-sized arteries,
which can reduce blood flow to tissues. This situation becomes particularly precarious when …

Most acute cardiovascular events are due to plaque rupture, with atheromas containing
large necrotic cores and thin fibrous caps being more susceptible to rupture and lesions with …

Atherosclerosis is a chronic inflammatory disorder characterized by the gradual build-up of
plaques within the vessel wall of middle-sized and large arteries. Over the past decades …

Atherosclerosis is a progressive inflammatory disorder of the arterial vessel wall
characterized by substantial infiltration of macrophages, which exert both favourable and …

Research points to pivotal roles for lipids in the development of atherosclerotic plaques.
Lipid-lowering statins substantially reduce acute coronary events resulting from plaque …

Plaque development and rupture are hallmarks of atherosclerotic vascular disease. Despite
current therapeutic developments, there is an unmet necessity in the prevention of …

Acute coronary syndromes result from fissure, erosion or rupture of a vulnerable
atherosclerotic plaque. The characteristics of a vulnerable plaque include a large lipid pool …