Sažetak Many biologic agents are weakly soluble in water. Therefore, they should be
dissolved in organic lipophilic solvents (vehicles). A drug vehicle is a substance of no …

Non-aqueous solvents have long been used in subcutaneous or intramuscular
pharmaceutical formulations to dissolve water-insoluble drugs. In recent years, the need for …

Natural bioactive compounds have been studied for a long time for their chemopreventive
and therapeutic potential in several chronic inflammatory diseases, including cancer …

While the advice and information in this book are believed to be true and accuate at the date
of going to press, neither the authors nor the editors nor the publisher can accept any legal …

Contact with many different biological membranes goes along the destiny of a drug after its
systemic administration. From the circulating macrophage cells to the vessel endothelium, to …

A more pronounced concern for pharmaceutical companies to detect and develop of new
drug molecules is observed and is expected. This is due, on the one hand exit under patent …

Abstract□ The effect of dilution of parenteral vehicles (organic cosolvent and 0.1 M
cyclodextrin solutions) on cultured endothelial cells (HUV-EC) were compared in vitro. Cell …

INTRODUCTION: Solubility is often a limiting factor when testing new compounds in animal
experiments. Various solubilizing agents may be used, but each have their own …

Currently, many of the drugs that are discovered or are on the market are not soluble in
water and they are classified in categories II and IV of the biopharmaceutical classification …

Abstract The Centers for Disease Control and Prevention (CDC) provides extensive data
that indicate our need for drugs to maintain human population health. Despite the …