Myocardial injury is the primary manifestation of multiple organ dysfunction during sepsis,
however, the mechanisms underlying sepsis‑induced myocardial injury remain unclear …

Inflammation and oxidative stress are implicated in the pathogenesis of acute viral
myocarditis (AVM). Ulinastantin (UTI), an inhibitor of serine protease widely used in …

Ulinastatin exerts protective effects against lipopolysaccharide (LPS)-induced cardiac
dysfunction. Autophagy has been demonstrated to serve an important role in sepsis‑induced …

Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome, remain the
leading causes of morbidity and mortality in intensive care units. Ulinastatin (UTI), a serine …

Autophagy is significant in myocardial ischemia‑reperfusion (IR) injury. Ulinastatin has been
demonstrated to protect cardiomyocytes against IR through inducing anti‑inflammatory …

Abstract CD4+ CD25+ regulatory T cells (Tregs) play an essential role in the suppression of
the immune response and prevention of autoimmune reactions. The activation of TLR4 …

Sepsis-induced myocardial dysfunction (SIMD) is one of the serious health-affecting
problems worldwide. At present, the mechanisms of SIMD are still not clearly elucidated. The …

The present study aimed to evaluate the effects of ulinastatin on the permeability and
apoptosis of lipopolysaccharide (LPS)-induced cardiac microvascular endothelial cells …

Myocardial injury and cardiovascular dysfunction are serious consequences of sepsis and
contribute to high mortality. Currently, the pathogenesis of myocardial injury in sepsis is still …

OBJECTIVE: The aim of this study was to investigate the effect of ulinastatin (UTI) on
myocardial ischemia-reperfusion injury (MIRI) through the c-Jun N-terminal kinase (JNK) …