Cyclophilin D (which is encoded by the Ppif gene) is a mitochondrial matrix peptidyl-prolyl
isomerase known to modulate opening of the mitochondrial permeability transition pore …

Mitochondria serve as a “powerhouse” which provides near 90% of ATP necessary for cell
life. However, recent studies provide strong evidence that mitochondria also play a central …

Abstract The Mitochondrial Permeability Transition (MPT) pore is a voltage-sensitive
unselective channel known to instigate necrotic cell death during cardiac disease. Recent …

Growing number of studies provide strong evidence that the mitochondrial permeability
transition pore (PTP), a non-selective channel in the inner mitochondrial membrane, is …

Cyclophilin D (CyPD) is an important mitochondrial chaperone protein whose mechanism of
action remains a mystery. It is well known for regulating mitochondrial function and coupling …

Cyclophilin D (CyPD) is thought to sensitize opening of the mitochondrial permeability
transition pore (mPTP) based on the findings that cyclosporin A (CsA), a pseudo-CyPD …

Mitochondria play a critical role in mediating both apoptotic and necrotic cell death. The
mitochondrial permeability transition (mPT) leads to mitochondrial swelling, outer membrane …

Background & Aims Hepatic ischemia/reperfusion injury is a complication of liver surgery
that involves mitochondrial dysfunction resulting from mitochondrial permeability transition …

The mitochondrial permeability transition pore (mPTP) plays a critical role in the
pathogenesis of cardiovascular diseases, including ischemia/reperfusion injury. Although …

Cyclophilin-D is a peptidylprolyl cis–trans isomerase of the mitochondrial matrix. It is
involved in mitochondrial permeability transition, in which the adenine nucleotide …