[HTML][HTML] Macrophages in osteoarthritis: pathophysiology and therapeutics

Y Chen, W Jiang, H Yong, M He, Y Yang… - American Journal of …, 2020 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is the most common cause of disability in worldwide population, which is
characterized by cartilage breakdown, synovial fibrosis, osteophyte formation and pain …

[HTML][HTML] The role of macrophages in osteoarthritis and cartilage repair

CL Wu, NS Harasymowicz, MA Klimak… - Osteoarthritis and …, 2020 - Elsevier
Osteoarthritis (OA) is a family of degenerative diseases affecting multiple joint tissues.
Despite the diverse etiology and pathogenesis of OA, increasing evidence suggests that …

[HTML][HTML] Synovial macrophages in osteoarthritis: the key to understanding pathogenesis?

A Thomson, CMU Hilkens - Frontiers in Immunology, 2021 - frontiersin.org
Effective treatment of osteoarthritis (OA) remains a huge clinical challenge despite major
research efforts. Different tissues and cell-types within the joint contribute to disease …

Clinical implications of macrophage dysfunction in the development of osteoarthritis of the knee

J Xie, Z Huang, X Yu, L Zhou, F Pei - Cytokine & growth factor reviews, 2019 - Elsevier
Osteoarthritis (OA) is the most common form of arthritic disease, leading to disability and
impaired quality of life and no curative treatments exist. Increasing evidence indicates that …

[HTML][HTML] Effects of synovial macrophages in osteoarthritis

K Zhao, J Ruan, L Nie, X Ye, J Li - Frontiers in immunology, 2023 - frontiersin.org
Osteoarthritis (OA) is a common degenerative disease in mammals. However, its
pathogenesis remains unclear. Studies indicate that OA is not only an aging process that but …

The role of macrophages in rheumatoid arthritis

Y Ma, RM Pope - Current pharmaceutical design, 2005 - ingentaconnect.com
Rheumatoid arthritis (RA) is a common autoimmune chronic inflammatory joint disease,
characterized by macrophage and lymphocyte infiltration, proliferation of synovial …

[图书][B] The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

J Bondeson, AB Blom, S Wainwright, C Hughes… - 2012 - academia.edu
Osteoarthritis (OA), one of the most common diseases among humans, is characterised
pathologically by focal areas of damage on articular cartilage centred on load-bearing …

[HTML][HTML] Innate inflammation and synovial macrophages in osteoarthritis pathophysiology

TM Griffin, CR Scanzello - Clinical and experimental rheumatology, 2019 - ncbi.nlm.nih.gov
Although osteoarthritis (OA) was historically referred to as the non-inflammatory arthritis, it is
now considered a condition involving persistent low-grade inflammation and activation of …

[HTML][HTML] Macrophages regulate the progression of osteoarthritis

H Zhang, D Cai, X Bai - Osteoarthritis and cartilage, 2020 - Elsevier
OA is now well accepted as a low-grade inflammatory disease affecting the whole joint. In
addition to mechanical loading, inflammation (particularly synovitis), contributes significantly …

[HTML][HTML] Macrophage: a potential target on cartilage regeneration

TL Fernandes, AH Gomoll, C Lattermann… - Frontiers in …, 2020 - frontiersin.org
Cartilage lesions and osteoarthritis (OA) presents an ever-increasing clinical and
socioeconomic burden. Synovial inflammation and articular inflammatory environment are …