Mortality after fluid bolus in African children with severe infection
K Maitland, S Kiguli, RO Opoka, C Engoru… - … England Journal of …, 2011 - Mass Medical Soc
Background The role of fluid resuscitation in the treatment of children with shock and life-
threatening infections who live in resource-limited settings is not established. Methods We …
threatening infections who live in resource-limited settings is not established. Methods We …
Effects of saline or albumin fluid bolus in resuscitation: evidence from re-analysis of the FEAST trial
M Levin, AJ Cunnington, C Wilson, S Nadel… - The Lancet …, 2019 - thelancet.com
Background Fluid resuscitation is the recommended management of shock, but increased
mortality in febrile African children in the FEAST trial. We hypothesised that fluid bolus …
mortality in febrile African children in the FEAST trial. We hypothesised that fluid bolus …
Exploring mechanisms of excess mortality with early fluid resuscitation: insightsfrom the FEAST trial
K Maitland, EC George, JA Evans, S Kiguli… - BMC medicine, 2013 - Springer
Background Early rapid fluid resuscitation (boluses) in African children with severe
febrileillnesses increases the 48-hour mortality by 3.3% compared with controls (nobolus) …
febrileillnesses increases the 48-hour mortality by 3.3% compared with controls (nobolus) …
Randomized trial of volume expansion with albumin or saline in children with severe malaria: preliminary evidence of albumin benefit
K Maitland, A Pamba, M English… - Clinical Infectious …, 2005 - academic.oup.com
Background. Metabolic acidosis is the best predictor of death in children with severe
falciparum malaria; however, its treatment presents a therapeutic dilemma, because …
falciparum malaria; however, its treatment presents a therapeutic dilemma, because …
Restricted fluid bolus volume in early septic shock: results of the Fluids in Shock pilot trial
DP Inwald, R Canter, K Woolfall, P Mouncey… - Archives of disease in …, 2019 - adc.bmj.com
Objective To determine the feasibility of Fluids in Shock, a randomised controlled trial (RCT)
of restricted fluid bolus volume (10 mL/kg) versus recommended practice (20 mL/kg). Design …
of restricted fluid bolus volume (10 mL/kg) versus recommended practice (20 mL/kg). Design …
Fluid bolus over 15–20 versus 5–10 minutes each in the first hour of resuscitation in children with septic shock: a randomized controlled trial
J Sankar, J Ismail, MJ Sankar, CP Suresh… - Pediatric Critical Care …, 2017 - journals.lww.com
Objectives: To compare the effect of administration of 40–60 mL/kg of fluids as fluid boluses
in aliquots of 20 mL/kg each over 15–20 minutes with that over 5–10 minutes each on the …
in aliquots of 20 mL/kg each over 15–20 minutes with that over 5–10 minutes each on the …
Time-and fluid-sensitive resuscitation for hemodynamic support of children in septic shock: barriers to the implementation of the American College of Critical Care …
CF Oliveira, FRN de Sá, DSF Oliveira… - Pediatric …, 2008 - journals.lww.com
Objectives: To analyze mortality rates of children with severe sepsis and septic shock in
relation to time-sensitive fluid resuscitation and treatments received and to define barriers to …
relation to time-sensitive fluid resuscitation and treatments received and to define barriers to …
Choice of fluids for resuscitation in children with severe infection and shock: systematic review
S Akech, H Ledermann, K Maitland - Bmj, 2010 - bmj.com
Objective To systemically review the evidence from clinical trials comparing the use of
crystalloids and colloids for fluid resuscitation in children with severe infection. Data sources …
crystalloids and colloids for fluid resuscitation in children with severe infection. Data sources …
A critique of fluid bolus resuscitation in severe sepsis
AK Hilton, R Bellomo - Critical Care, 2012 - Springer
Resuscitation of septic patients by means of one or more fluid boluses is recommended by
guidelines from multiple relevant organizations and as a component of surviving sepsis …
guidelines from multiple relevant organizations and as a component of surviving sepsis …
Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness
Background Severe anaemia in children is a leading cause of hospital admission and a
major cause of mortality in sub-Saharan Africa, yet there are limited published data on blood …
major cause of mortality in sub-Saharan Africa, yet there are limited published data on blood …
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