Background The role of fluid resuscitation in the treatment of children with shock and life-
threatening infections who live in resource-limited settings is not established. Methods We …

Background Fluid resuscitation is the recommended management of shock, but increased
mortality in febrile African children in the FEAST trial. We hypothesised that fluid bolus …

Background Early rapid fluid resuscitation (boluses) in African children with severe
febrileillnesses increases the 48-hour mortality by 3.3% compared with controls (nobolus) …

Background. Metabolic acidosis is the best predictor of death in children with severe
falciparum malaria; however, its treatment presents a therapeutic dilemma, because …

Objective To determine the feasibility of Fluids in Shock, a randomised controlled trial (RCT)
of restricted fluid bolus volume (10 mL/kg) versus recommended practice (20 mL/kg). Design …

Objectives: To compare the effect of administration of 40–60 mL/kg of fluids as fluid boluses
in aliquots of 20 mL/kg each over 15–20 minutes with that over 5–10 minutes each on the …

Objectives: To analyze mortality rates of children with severe sepsis and septic shock in
relation to time-sensitive fluid resuscitation and treatments received and to define barriers to …

Objective To systemically review the evidence from clinical trials comparing the use of
crystalloids and colloids for fluid resuscitation in children with severe infection. Data sources …

Resuscitation of septic patients by means of one or more fluid boluses is recommended by
guidelines from multiple relevant organizations and as a component of surviving sepsis …

Background Severe anaemia in children is a leading cause of hospital admission and a
major cause of mortality in sub-Saharan Africa, yet there are limited published data on blood …