Bacteriophages as drivers of bacterial virulence and their potential for biotechnological exploitation

K Schroven, A Aertsen, R Lavigne - FEMS microbiology reviews, 2021 - academic.oup.com
Bacteria-infecting viruses (phages) and their hosts maintain an ancient and complex
relationship. Bacterial predation by lytic phages drives an ongoing phage-host arms race …

Importance of prophages to evolution and virulence of bacterial pathogens

LC Fortier, O Sekulovic - Virulence, 2013 - Taylor & Francis
Bacteriophages, or simply phages, are viruses infecting bacteria. With an estimated 1031
particles in the biosphere, phages outnumber bacteria by a factor of at least 10 and not …

[HTML][HTML] Beyond antibacterials–exploring bacteriophages as antivirulence agents

Y Shen, MJ Loessner - Current Opinion in Biotechnology, 2021 - Elsevier
Highlights•Surface receptor-mediated phage resistance often comes at a cost for
fitness.•Possible trade-offs may include attenuated virulence, and increased sensitivity to …

The disparate effects of bacteriophages on antibiotic-resistant bacteria

C Torres-Barceló - Emerging microbes & infections, 2018 - Taylor & Francis
Faced with the crisis of multidrug-resistant bacteria, bacteriophages, viruses that infect and
replicate within bacteria, have been reported to have both beneficial and detrimental effects …

[HTML][HTML] Bacteriophage-based tools: recent advances and novel applications

L O'sullivan, C Buttimer, O McAuliffe, D Bolton… - …, 2016 - ncbi.nlm.nih.gov
Bacteriophages (phages) are viruses that infect bacterial hosts, and since their discovery
over a century ago they have been primarily exploited to control bacterial populations and to …

Bacteriophage-mediated spread of bacterial virulence genes

JR Penadés, J Chen, N Quiles-Puchalt… - Current opinion in …, 2015 - Elsevier
Highlights•Phage-mediated transduction drives bacterial evolution.•pac-phages can
package any bacterial DNA.•Both pac and cos phages can transfer mobile genetic …

Bacteriophages as biotechnological tools

MA Elois, R Silva, GVT Pilati, D Rodríguez-Lázaro… - Viruses, 2023 - mdpi.com
Bacteriophages are ubiquitous organisms that can be specific to one or multiple strains of
hosts, in addition to being the most abundant entities on the planet. It is estimated that they …

Bacteriophage control of bacterial virulence

PL Wagner, MK Waldor - Infection and immunity, 2002 - Am Soc Microbiol
In 1930, Felix d'Herelle wrote “... the actions and reactions are not solely between these two
beings, man and bacterium, for the bacteriophage also intervenes; a third living being and …

[HTML][HTML] Bacteriophage procurement for therapeutic purposes

B Weber-Dąbrowska, E Jończyk-Matysiak… - Frontiers in …, 2016 - frontiersin.org
Bacteriophages (phages), discovered 100 years ago, are able to infect and destroy only
bacterial cells. In the current crisis of antibiotic efficacy, phage therapy is considered as a …

Exploiting bacteriophage proteomes: the hidden biotechnological potential

SB Santos, AR Costa, C Carvalho, FL Nóbrega… - Trends in …, 2018 - cell.com
Bacteriophages encode many distinct proteins for the successful infection of a bacterial host.
Each protein plays a specific role in the phage replication cycle, from host recognition …