Problem The inflammasome is implicated in the mechanisms that lead to spontaneous
preterm labor (PTL). However, whether there is inflammasome activation in the amniotic …

Background The inflammasome has been implicated in the mechanisms that lead to
spontaneous labor at term. However, whether the inflammasome is activated in the amniotic …

Inflammasomes are cytosolic multiprotein complexes that orchestrate inflammation in
response to pathogens and endogenous danger signals. Herein, we determined whether …

Problem Inflammasome activation requires two steps: priming and assembly of the
multimeric complex. The second step includes assembly of the sensor molecule and adaptor …

Problem Inflammasomes are signaling platforms that, upon sensing pathogens and sterile
stressors, mediate the release of mature forms of interleukin (IL)‐1β and IL‐18. The aims of …

Inflammasomes are cytosolic signaling platforms that regulate the activation of caspase
(CASP)-1, which induces the maturation of interleukin (IL)-1β and IL-18. Herein, we …

Objective: Upon inflammasome activation, the adaptor protein of the inflammasome ASC
(apoptosis-associated speck-like protein containing a CARD) forms intracellular specks …

Objective. Caspase-1 is a component of the NALP3 inflammasome, a cytosolic multiprotein
complex that mediates the processing of pro-inflammatory caspases and cytokines. The …

Background Intra-amniotic inflammation, which is associated with adverse pregnancy
outcomes, can occur in the presence or absence of detectable microorganisms, and …

PROBLEM: This study was conducted to determine whether:(1) gestational age, parturition,
and microbial invasion of the amniotic cavity (MIAC) are associated with changes in amniotic …