[HTML][HTML] Embryonic development following somatic cell nuclear transfer impeded by persisting histone methylation
Mammalian oocytes can reprogram somatic cells into a totipotent state enabling animal
cloning through somatic cell nuclear transfer (SCNT). However, the majority of SCNT …
cloning through somatic cell nuclear transfer (SCNT). However, the majority of SCNT …
[HTML][HTML] Inhibition of aberrant DNA re-methylation improves post-implantation development of somatic cell nuclear transfer embryos
Somatic cell nuclear transfer (SCNT) enables cloning of differentiated cells by
reprogramming their nuclei to a totipotent state. However, successful full-term development …
reprogramming their nuclei to a totipotent state. However, successful full-term development …
[HTML][HTML] H3K4 methylation-dependent memory of somatic cell identity inhibits reprogramming and development of nuclear transfer embryos
E Hörmanseder, A Simeone, GE Allen, CR Bradshaw… - Cell stem cell, 2017 - cell.com
Vertebrate eggs can induce the nuclear reprogramming of somatic cells to enable
production of cloned animals. Nuclear reprogramming is relatively inefficient, and the …
production of cloned animals. Nuclear reprogramming is relatively inefficient, and the …
[HTML][HTML] Histone demethylase expression enhances human somatic cell nuclear transfer efficiency and promotes derivation of pluripotent stem cells
The extremely low efficiency of human embryonic stem cell (hESC) derivation using somatic
cell nuclear transfer (SCNT) limits its potential application. Blastocyst formation from human …
cell nuclear transfer (SCNT) limits its potential application. Blastocyst formation from human …
[HTML][HTML] Loss of H3K27me3 imprinting in somatic cell nuclear transfer embryos disrupts post-implantation development
Animal cloning can be achieved through somatic cell nuclear transfer (SCNT), although the
live birth rate is relatively low. Recent studies have identified H3K9me3 in donor cells and …
live birth rate is relatively low. Recent studies have identified H3K9me3 in donor cells and …
Epigenetic modification is central to genome reprogramming in somatic cell nuclear transfer
The recent high-profile reports of the derivation of human embryonic stem cells (ESCs) from
human blastocysts produced by somatic cell nuclear transfer (SCNT) have highlighted the …
human blastocysts produced by somatic cell nuclear transfer (SCNT) have highlighted the …
H3K27me3 is an epigenetic barrier while KDM6A overexpression improves nuclear reprogramming efficiency
C Zhou, Y Wang, J Zhang, J Su, Q An, X Liu… - The FASEB …, 2019 - Wiley Online Library
Aberrant epigenetic reprogramming is a major factor of developmental failure of cloned
embryos. Histone H3 lysine 27 trimethylation (H3K27me3), a histone mark for transcriptional …
embryos. Histone H3 lysine 27 trimethylation (H3K27me3), a histone mark for transcriptional …
[HTML][HTML] Epigenetic reprogramming during somatic cell nuclear transfer: recent progress and future directions
X Wang, J Qu, J Li, H He, Z Liu, Y Huan - Frontiers in Genetics, 2020 - frontiersin.org
Somatic cell nuclear transfer (SCNT) has broad applications but is limited by low cloning
efficiency. In this review, we mainly focus on SCNT-mediated epigenetic reprogramming in …
efficiency. In this review, we mainly focus on SCNT-mediated epigenetic reprogramming in …
[HTML][HTML] Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing
W Liu, X Liu, C Wang, Y Gao, R Gao, X Kou, Y Zhao… - Cell discovery, 2016 - nature.com
Differentiated somatic cells can be reprogrammed into totipotent embryos through somatic
cell nuclear transfer. However, most cloned embryos arrest at early stages and the …
cell nuclear transfer. However, most cloned embryos arrest at early stages and the …
[HTML][HTML] Unreprogrammed H3K9me3 prevents minor zygotic genome activation and lineage commitment in SCNT embryos
Somatic cell nuclear transfer (SCNT) can be used to reprogram differentiated somatic cells
to a totipotent state but has poor efficiency in supporting full-term development. H3K9me3 is …
to a totipotent state but has poor efficiency in supporting full-term development. H3K9me3 is …