Introduction: Drug discovery is a lengthy interdisciplinary approach. However, a much
cheaper and less consuming predrug approach is a promising and well-established strategy …

Prodrugs, the pharmacologically inactive derivatives of active drugs, are designed to
maximize the amount of active drug that reaches its site of action, through manipulation of …

The prodrug approach to resolving formulation, delivery, and toxicity limitations on
problematic drugs has had its proponents and detractors. Over the last 10 years or so, about …

Prodrugs are bioreversible derivatives of pharmacologically active agents that must undergo
an enzymatic and/or chemical transformation in vivo to release the active parent drug, which …

A drug is a chemical substance which possesses medicinal properties and exerts
pharmacological action upon administration into the body. When a drug gets metabolized …

The process of drug discovery has been changed considerably during the last decade.
Modern drug discovery technologies such as computer-aided drug design, combinatorial …

Prodrugs are bioreversible, inactive drug derivatives, which have the ability to convert into a
parent drug in the body. In the past, prodrugs were used as a last option; however …

The prodrug concept has been used to improve undesirable properties of drugs since the
late 19th century, although it was only at the end of the 1950s that the actual term prodrug …

Prodrug Design: Perspectives, Approaches and Applications in Medicinal Chemistry
provides a focused overview of this critical area of drug discovery, as that continuous …

Prodrugs are bioreversible derivatives of drug molecules that undergo an enzymatic and/or
chemical transformation in vivo to release the active parent drug, which can then exert the …