System-based proteomic and metabonomic analysis of the Df (16) A+/− mouse identifies potential miR-185 targets and molecular pathway alterations
Abstract Deletions on chromosome 22q11. 2 are a strong genetic risk factor for development
of schizophrenia and cognitive dysfunction. We employed shotgun liquid chromatography …
of schizophrenia and cognitive dysfunction. We employed shotgun liquid chromatography …
Untargeted metabolomic, and proteomic analysis identifies metabolic biomarkers and pathway alterations in individuals with 22q11. 2 deletion syndrome
M Zafarullah, K Angkustsiri, A Quach, S Yeo… - Metabolomics, 2024 - Springer
Abstract Introduction The chromosome 22q11. 2 deletion syndrome (22q11. 2DS) is
characterized by a well-defined microdeletion and is associated with a wide range of brain …
characterized by a well-defined microdeletion and is associated with a wide range of brain …
Convergent and distributed effects of the 3q29 deletion on the human neural transcriptome
Abstract The 3q29 deletion (3q29Del) confers high risk for schizophrenia and other
neurodevelopmental and psychiatric disorders. However, no single gene in this interval is …
neurodevelopmental and psychiatric disorders. However, no single gene in this interval is …
Df (h15q13)/+ mouse model reveals loss of astrocytes and synaptic-related changes of the excitatory and inhibitory circuits in the medial prefrontal cortex
Abstract The 15q13. 3 deletion is associated with multiple neurodevelopmental disorders
including epilepsy, schizophrenia, and autism. The Df (h15q13)/+ mouse model was …
including epilepsy, schizophrenia, and autism. The Df (h15q13)/+ mouse model was …
Differential gene expression in the hippocampus of the Df1/+ mice: a model for 22q11. 2 deletion syndrome and schizophrenia
S Sivagnanasundaram, D Fletcher, M Hubank… - Brain research, 2007 - Elsevier
Genes and a 3-Mb deletion mapping to human chromosome 22q11. 2 have been implicated
in 22q11. 2 deletion syndrome (22q11. 2DS) and schizophrenia. The Df1 heterozygous …
in 22q11. 2 deletion syndrome (22q11. 2DS) and schizophrenia. The Df1 heterozygous …
Neuroanatomical phenotypes in a mouse model of the 22q11. 2 microdeletion
Recurrent deletions at the 22q11. 2 locus have been established as a strong genetic risk
factor for the development of schizophrenia and cognitive dysfunction. Individuals with …
factor for the development of schizophrenia and cognitive dysfunction. Individuals with …
Transcriptome profiling of peripheral blood in 22q11. 2 deletion syndrome reveals functional pathways related to psychosis and autism spectrum disorder
Background 22q11. 2 Deletion Syndrome (22q11DS) represents one of the greatest known
genetic risk factors for the development of psychotic illness, and is also associated with high …
genetic risk factors for the development of psychotic illness, and is also associated with high …
MicroRNAs as the cause of schizophrenia in 22q11. 2 deletion carriers, and possible implications for idiopathic disease: a mini-review
AJ Forstner, F Degenhardt, G Schratt… - Frontiers in molecular …, 2013 - frontiersin.org
The 22q11. 2 deletion is the strongest known genetic risk factor for schizophrenia. Research
has implicated microRNA-mediated dysregulation in 22q11. 2 deletion syndrome (22q11 …
has implicated microRNA-mediated dysregulation in 22q11. 2 deletion syndrome (22q11 …
Functional gene-expression analysis shows involvement of schizophrenia-relevant pathways in patients with 22q11 deletion syndrome
NJM van Beveren, LC Krab, S Swagemakers… - PLoS …, 2012 - journals.plos.org
22q11 Deletion Syndrome (22q11DS) is associated with dysmorphology and a high
prevalence of schizophrenia-like symptoms. Several genes located on chromosome 22q11 …
prevalence of schizophrenia-like symptoms. Several genes located on chromosome 22q11 …
MicroRNA dysregulation, gene networks, and risk for schizophrenia in 22q11. 2 deletion syndrome
The role of microRNAs (miRNAs) in the etiology of schizophrenia is increasingly recognized.
Microdeletions at chromosome 22q11. 2 are recurrent structural variants that impart a high …
Microdeletions at chromosome 22q11. 2 are recurrent structural variants that impart a high …
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