Insulin resistance is a key defect associated with obesity and type-2 diabetes. The precise
factors that lead to insulin resistance have not been elucidated fully, but there is a strong …

The precise cause of insulin resistance and type 2 diabetes is unknown. However, there is a
strong association between insulin resistance and lipid accumulation—and, in particular …

Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in
insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of …

The contribution of mitochondrial dysfunction to insulin resistance is a contentious issue in
metabolic research. Recent evidence implicates mitochondrial dysfunction as contributing to …

Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR);
however, a large variety of association and intervention studies as well as genetic …

Insulin resistance (IR) is fundamental to the development of type 2 diabetes (T2D) and is
present in most prediabetic (preDM) individuals. Insulin resistance has both heritable and …

The specific cellular underpinnings or mechanisms of insulin resistance (IR) are not clear.
Here I present evidence to support a causal association between mitochondrial energetics …

Insulin resistance in skeletal muscle is a major hallmark of type 2 diabetes mellitus (T2D)
and obesity that is characterized by impaired insulin-mediated glucose transport and …

Insulin resistance,“a relative impairment in the ability of insulin to exert its effects on glucose,
protein and lipid metabolism in target tissues,” has many detrimental effects on metabolism …

Insulin resistance is a characteristic feature of type 2 diabetes mellitus, obesity, and the
metabolic syndrome. Increased intracellular fat content in skeletal muscle and liver …