Introduction Prolonged infusion with β-lactam antibiotics should theoretically produce a
better clinical efficacy than intermittent infusion in severe infection and infection caused by …

The clinical advantages of prolonged (extended/continuous) infusion remain controversial.
Previous studies and reviews have failed to show consistent clinical benefits of extending …

Objective This overview of reviews aims to map and compare of objectives, methods, and
findings of existing systematic reviews to develop a greater understanding of the information …

Introduction Our objective is to determine whether prolonged infusion (PI) of beta-lactam
antibiotics yields superior outcomes compared to intermittent infusion (II) in patients with …

Prolonged infusion of beta-lactam antibiotics for Gram-negat... : Current Opinion in
Infectious Diseases Prolonged infusion of beta-lactam antibiotics for Gram-negative …

Given the sparse antibiotic pipeline and the increasing prevalence of resistant organisms,
efforts should be made to optimise the pharmacodynamic exposure of currently available …

Continuous infusion of β-lactam antibiotics has been widely promoted to optimise their time-
dependent activity. Increasing evidence is emerging suggesting potential benefits in patient …

Background The prolonged β-lactam antibiotics infusion has been an attractive strategy in
severe infections, because it provides a more stable free drug concentration and a longer …

Background The two latest studies on prolonged versus intermittent use of β-lactam
antibiotics in patients with sepsis did not reach consistent conclusions, further contributing to …

Importance There is uncertainty about whether prolonged infusions of β-lactam antibiotics
improve clinically important outcomes in critically ill adults with sepsis or septic shock …