Background ABC transporter-mediated multidrug resistance (MDR) remains a major
obstacle for cancer pharmacological treatment. Some tyrosine kinase inhibitors (TKIs) have …

ATP-binding cassette transporters, including ABCB1 (P-glycoprotein) and ABCG2
(BCRP/MXR/ABCP), are pivotal in multidrug resistance (MDR) development in cancer …

Multidrug resistance (MDR) triggered by ATP binding cassette (ABC) transporter such as
ABCB1, ABCC1, ABCG2 limited successful cancer chemotherapy. Unfortunately, no …

ATP-Binding Cassette transporters are involved in the efflux of xenobiotic compounds and
are responsible for decreasing drug accumulation in multidrug resistant (MDR) cells …

The main characteristic of tumor cell resistance is multidrug resistance (MDR). MDR is the
principle cause of the decline in clinical efficacy of chemotherapeutic drugs. There are …

Overexpression of ABCB1 transporters plays a crucial role in mediating multidrug resistance
(MDR). Therefore, it is important to inhibit ABCB1 activity in order to maintain an effective …

Simple Summary ABC transporters comprise a large group of ATP binding plasma
membrane proteins, classified into subfamilies AG, that transport substrates out of cells to …

Multidrug resistance (MDR) to chemotherapeutic drugs is a formidable barrier to the success
of cancer chemotherapy. Expressions of ATP-binding cassette (ABC) transporters contribute …

The frequent occurrence of multidrug resistance (MDR) conferred by the overexpression of
ATP-binding cassette (ABC) transporters ABCB1 and ABCG2 in cancer cells remains a …

The development of multidrug resistance (MDR) to chemotherapy remains a major
challenge in the treatment of cancer. Numerous mechanisms have been recognized that …