Nanoparticles insert a three dimensional cavity structure of proteins for function inhibition: The Case of CeO2 and SARS-CoV-2
The selective interaction of nanomaterials with proteins for protein function suppression has
been reported. However, whether the nanomaterials could be used to target a three …
been reported. However, whether the nanomaterials could be used to target a three …
Enhanced binding of SARS-CoV-2 spike protein to receptor by distal polybasic cleavage sites
B Qiao, M Olvera de la Cruz - ACS nano, 2020 - ACS Publications
The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein plays a crucial role in
binding the human cell receptor ACE2 that is required for viral entry. Many studies have …
binding the human cell receptor ACE2 that is required for viral entry. Many studies have …
Binding mechanism of neutralizing nanobodies targeting SARS-CoV-2 spike glycoprotein
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters human cells upon
binding of its spike (S) glycoproteins to ACE2 receptors. Several nanobodies neutralize …
binding of its spike (S) glycoproteins to ACE2 receptors. Several nanobodies neutralize …
Host-Directed Virus-Mimicking Particles Interacting with the ACE2 Receptor Competitively Block Coronavirus SARS-CoV-2 Entry
P Zhang, E Niemelä, S López Cerdá, P Sorvisto… - Nano Letters, 2024 - ACS Publications
Herein, we fabricate host-directed virus-mimicking particles (VMPs) to block the entry of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into host cells through …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into host cells through …
Nano-targeting lessons from the SARS-CoV-2
IRS Ribeiro, RF da Silva, CP Silveira, FE Galdino… - Nano Today, 2021 - Elsevier
The lack of targeting efficacy has frequently led functionalized nanoparticles to accumulate
in unwanted cells and tissues while boosting toxicity-related effects. Conversely, viruses are …
in unwanted cells and tissues while boosting toxicity-related effects. Conversely, viruses are …
Anti-SARS-CoV-1 and− 2 nanobody engineering towards avidity-inspired therapeutics
In the past two decades, the emergence of coronavirus diseases has been dire distress on
both continental and global fronts and has resulted in the search for potent treatment …
both continental and global fronts and has resulted in the search for potent treatment …
Key residues of the receptor binding domain in the spike protein of SARS-CoV-2 mediating the interactions with ACE2: a molecular dynamics study
The widespread coronavirus disease 2019 (COVID-19) has been declared a global health
emergency. As one of the most important targets for antibody and drug developments, the …
emergency. As one of the most important targets for antibody and drug developments, the …
[HTML][HTML] Inhibition of SARS-CoV-2 Spike Protein Pseudotyped Virus Infection Using ACE2-Tethered Micro/Nanoparticles
SY Alkhaldi, I Peng, CA Peng - Bioengineering, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19) has caused a global pandemic of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The viral infection is reliant upon the …
respiratory syndrome coronavirus 2 (SARS-CoV-2). The viral infection is reliant upon the …
[HTML][HTML] An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages
Rationale: Macrophages are the frontline immune cells in response to severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Angiotensin-converting …
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Angiotensin-converting …
[HTML][HTML] A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-CoV-2 virus and the Omicron variant BA. 1 through a unique binding mode
D Zhao, L Liu, X Liu, J Zhang, Y Yin, L Luan… - Journal of …, 2022 - Springer
The major challenge to controlling the COVID pandemic is the rapid mutation rate of the
SARS-CoV-2 virus, leading to the escape of the protection of vaccines and most of the …
SARS-CoV-2 virus, leading to the escape of the protection of vaccines and most of the …
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