Nanoparticles insert a three dimensional cavity structure of proteins for function inhibition: The Case of CeO2 and SARS-CoV-2

G Zhang, X Wang, G Wang, X Suo, Y Qiu, RH Luo… - Nano Today, 2024 - Elsevier
The selective interaction of nanomaterials with proteins for protein function suppression has
been reported. However, whether the nanomaterials could be used to target a three …

Enhanced binding of SARS-CoV-2 spike protein to receptor by distal polybasic cleavage sites

B Qiao, M Olvera de la Cruz - ACS nano, 2020 - ACS Publications
The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein plays a crucial role in
binding the human cell receptor ACE2 that is required for viral entry. Many studies have …

Binding mechanism of neutralizing nanobodies targeting SARS-CoV-2 spike glycoprotein

M Golcuk, A Hacisuleyman, B Erman… - Journal of Chemical …, 2021 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters human cells upon
binding of its spike (S) glycoproteins to ACE2 receptors. Several nanobodies neutralize …

Host-Directed Virus-Mimicking Particles Interacting with the ACE2 Receptor Competitively Block Coronavirus SARS-CoV-2 Entry

P Zhang, E Niemelä, S López Cerdá, P Sorvisto… - Nano Letters, 2024 - ACS Publications
Herein, we fabricate host-directed virus-mimicking particles (VMPs) to block the entry of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into host cells through …

Nano-targeting lessons from the SARS-CoV-2

IRS Ribeiro, RF da Silva, CP Silveira, FE Galdino… - Nano Today, 2021 - Elsevier
The lack of targeting efficacy has frequently led functionalized nanoparticles to accumulate
in unwanted cells and tissues while boosting toxicity-related effects. Conversely, viruses are …

Anti-SARS-CoV-1 and− 2 nanobody engineering towards avidity-inspired therapeutics

EM Obeng, CKO Dzuvor, MK Danquah - Nano Today, 2022 - Elsevier
In the past two decades, the emergence of coronavirus diseases has been dire distress on
both continental and global fronts and has resulted in the search for potent treatment …

Key residues of the receptor binding domain in the spike protein of SARS-CoV-2 mediating the interactions with ACE2: a molecular dynamics study

Y Yang, Y Zhang, Y Qu, C Zhang, XW Liu, M Zhao… - Nanoscale, 2021 - pubs.rsc.org
The widespread coronavirus disease 2019 (COVID-19) has been declared a global health
emergency. As one of the most important targets for antibody and drug developments, the …

[HTML][HTML] Inhibition of SARS-CoV-2 Spike Protein Pseudotyped Virus Infection Using ACE2-Tethered Micro/Nanoparticles

SY Alkhaldi, I Peng, CA Peng - Bioengineering, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19) has caused a global pandemic of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The viral infection is reliant upon the …

[HTML][HTML] An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages

S Satta, Z Meng, R Hernandez, S Cavallero, T Zhou… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Macrophages are the frontline immune cells in response to severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Angiotensin-converting …

[HTML][HTML] A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-CoV-2 virus and the Omicron variant BA. 1 through a unique binding mode

D Zhao, L Liu, X Liu, J Zhang, Y Yin, L Luan… - Journal of …, 2022 - Springer
The major challenge to controlling the COVID pandemic is the rapid mutation rate of the
SARS-CoV-2 virus, leading to the escape of the protection of vaccines and most of the …