Acetaminophen (APAP) overdose can cause severe liver injury and acute liver failure. The
only clinically approved antidote, N‐acetylcysteine (NAC), is highly effective but has a …

Acetaminophen (APAP) known as paracetamol is the main ingredient in Tylenol, which has
analgesic and anti-pyretic properties. Inappropriate use of APAP causes major morbidity …

Nrf2, which belongs to the basic leucine zipper (bZip) transcription factor family, has been
implicated as a key molecule involved in antioxidant-responsive element (ARE)-mediated …

Acetaminophen (APAP) overdose stands as the primary cause of acute liver failure in the
United States. APAP hepatotoxicity involves hepatic glutathione (GSH) depletion and …

The transcription factor Nrf2 regulates the expression of numerous cytoprotective genes in
mammalian cells. We have demonstrated previously that acetaminophen activates Nrf2 in …

Background and Aims Acetaminophen (APAP) overdose induces severe liver injury and
hepatic failure. While the activation of c‐Jun NH2‐terminal kinase (JNK) has been …

Acetaminophen (APAP) is a widely used analgesic and antipyretic over-the-counter
medicine worldwide. Hepatotoxicity caused by APAP overdose is one of the leading causes …

Acetaminophen (APAP) is the most used non-prescription drug throughout the world. At
therapeutic doses, APAP has potent analgesic and antipyretic effects. The efficacy and …

Acetaminophen (AA) is a widely used antipyretic drug that causes hepatotoxicity at high
doses. Nuclear factor erythroid 2–related factor 2 (Nrf2) is a transcription factor that mitigates …

Acetaminophen (APAP) is the most popular mild analgesic and antipyretic drug used
worldwide. APAP overdose leads to drug-induced hepatotoxicity and can cause hepatic …