The discovery of anti-podocyte antibodies in primary membranous nephropathy (MN) has
revolutionized our approach toward the diagnosis and treatment of this disease. Evaluation …

The discovery of circulating antibodies specific for native podocyte antigens has transformed
the diagnostic workup and greatly improved management of idiopathic membranous …

Membranous nephropathy (MN), an autoimmune kidney disease and leading cause of
nephrotic syndrome, leads to kidney failure in up to one-third of affected individuals. Most …

Results At diagnosis, 182 (64%), eight (3%), and 95 (33%) patients were anti-PLA2R1+, anti-
THSD7A+, and double negative, respectively. The prevalence of a detectable antibody to at …

Results IgG 4 was the most common isotype for all antibodies; IgG 1 and IgG 3 were nearly
negligible. IgG 4 levels were positive in a significant proportion of MN patients (AR, 34%; …

Primary membranous nephropathy (MN) is an autoimmune disease mainly caused by
autoantibodies against the recently discovered podocyte antigens: the M-type …

The identification of the phospholipase A2 receptor 1 (PLA2R) and thrombospondin type-1
domain-containing protein 7A (THSD7A) as podocyte antigens in adult patients with …

A variety of podocyte antigens have been identified in human membranous nephropathy
(MN), which is divided into various antigen-dominated subtypes, confirming the concept that …

Membranous nephropathy is a frequent cause of nephrotic syndrome in adults. In most
patients, it appears as a primary renal disease but in about 20% of cases membranous …

Primary membranous nephropathy is a leading cause of adult nephrotic syndrome. The field
took a major step forward with the identification of phospholipase A2 receptor (PLA2R) as a …