Alzheimer's disease (AD) is a neurodegenerative disease mainly characterized by
progressive cognitive dysfunction and memory impairment. Recent studies have shown that …

Alzheimer's disease (AD) is the most common neurodegenerative disease, and its incidence
is increasing worldwide with increased lifespan. Currently, there is no effective treatment to …

Sirtuins (SIRT) are a class of histone deacetylases that regulate important metabolic
pathways and play a role in several disease processes. Of the seven mammalian homologs …

Natural products have long been used as drugs to treat a wide array of human diseases.
The lead compounds discovered from natural sources are used as novel templates for …

Alzheimer's disease (AD) is the most common cause of dementia and cognitive impairment;
yet, there is currently no treatment. A buildup of Aβ, tau protein phosphorylation, oxidative …

Silent information regulator (SIRT) has distinctive enzymatic activities and physiological
functions to control cell-cycle progression, gene expression, and DNA stability by targeting …

Aims Alzheimer's disease (AD) is the most prevalent age-related disease and the most
common cause of dementia in the elderly. Its hallmark neuropathological features are the …

Background. Recent studies suggest a correlation between the reduced Sirt‐1 expression
with Alzheimer's diseases (AD) and depression, respectively, suggesting a possible …

SIRT3, the primary mitochondrial deacetylase, regulates the functions of mitochondrial
proteins including metabolic enzymes and respiratory chain components. Although SIRT3's …

Alzheimer's disease (AD) is the most prevalent cause of dementia in the aging population
worldwide. SIRT1 deacetylation of histones and transcription factors impinge on multiple …