After maternal predetermination gives way to zygotic regulation, a ground state is
established within the mammalian embryo. This tabula rasa for embryogenesis is present …

It has been 8 years since the concept of naïve and primed pluripotent stem cell states was
first proposed. Both are states of pluripotency, but exhibit slightly different properties. The …

Pluripotency defines the propensity of a cell to differentiate into, and generate, all somatic,
as well as germ cells. The epiblast of the early mammalian embryo is the founder population …

Pluripotency denotes the flexible capacity of single cells to give rise to all somatic lineages
and typically also the germline. Mouse ES cells and post‐implantation epiblast‐derived stem …

Pluripotent cells in the mammalian embryo undergo state transitions marked by changes in
patterns of gene expression and developmental potential as they progress from pre …

Understanding the basis of the unrestricted multilineage differentiation potential of
pluripotent cells will be of developmental and translational consequence. We propose that …

In the mouse, naïve pluripotent stem cells (PSCs) are thought to represent the cell culture
equivalent of the late epiblast in the pre-implantation embryo, with which they share a …

Recent studies have aimed to convert cultured human pluripotent cells to a naive state, but it
remains unclear to what extent the resulting cells recapitulate in vivo naive pluripotency …

Specific cells within the early mammalian embryo have the capacity to generate all somatic
lineages plus the germline. This property of pluripotency is confined to the epiblast, a …

Pluripotency manifests during mammalian development through formation of the epiblast,
founder tissue of the embryo proper. Rodent pluripotent stem cells can be considered as two …