The acquisition of distinct neuronal fates is fundamental for the function of the cerebral
cortex. We find that the development of subcerebral projections from layer 5 neurons in the …

The molecular linkage between neocortical projection neuron subtype and area
development, which enables the establishment of functional areas by projection neuron …

Neurons within each layer in the mammalian cortex have stereotypic projections. Four
genes—Fezf2, Ctip2, Tbr1, and Satb2—regulate these projection identities. These genes …

Here we review the mechanisms that determine projection neuron identity during cortical
development. Pyramidal neurons in the mammalian cerebral cortex can be classified into …

While transcriptional controls over the size and relative position of cortical areas have been
identified, less is known about regulators that direct acquisition of area-specific …

Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression.
In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the …

During cortical development, the identity of major classes of long-distance projection
neurons is established by the expression of molecular determinants, which become …

The molecular mechanisms regulating fate divergence of closely related, but distinct, layer 6
corticothalamic and layer 5 subcerebral projection neurons are largely unknown. We …

A unique combination of transcription factor expression and projection neuron identity
demarcates each layer of the cerebral cortex. During mouse and human cortical …

The pyramidal neurons of the mammalian neocortex form two major types of long-range
connections—corticocortical and cortico-subcortical. The transcription factors Satb2 and …