Mice deficient for SIRT6 exhibit a severely shortened lifespan, growth retardation, and highly
elevated LINE1 (L1) activity. Here we report that SIRT6-deficient cells and tissues …

The human body has a remarkable ability to regulate inflammation, a biophysical response
triggered by virus infection and tissue damage. Sirt6 is critical for metabolism and lifespan; …

Calorie restriction (CR) extends lifespan from yeast to mammals. SIRT6 is a member of the
sirtuin family of NAD+-dependent histone deacetylases, which is responsible for mediating …

Macrophage activation and infiltration into resident tissues is known to mediate local
inflammation and is a hallmark feature of metabolic syndrome. Members of the sirtuin family …

The aging process involves changes in immune regulation, ie adaptive immunity declines
whereas innate immunity becomes activated. NF-kB signaling is the master regulator of the …

SIRT7, a sirtuin family member implicated in aging and disease, is a regulator of metabolism
and stress responses. It remains elusive how human somatic stem cell populations might be …

It is well documented that the rate of aging can be slowed, but it remains unclear to which
extent aging-associated conditions can be reversed. How the interface of immunity and …

Summary The mammalian Sir2 ortholog Sirt1 plays an important role in metabolic
regulation. However, the role of Sirt1 in the regulation of aging and longevity is still …

Despite recent controversy about their function in some organisms, sirtuins are thought to
play evolutionarily conserved roles in lifespan extension. Whether sirtuins can reverse aging …

Innate antiviral immunity deteriorates with aging but how this occurs is not entirely clear.
Here we identified SIRT1-mediated DNA-binding domain (DBD) deacetylation as a critical …