Why Most Clinical Research Is Not Useful | PLOS Medicine Skip to main content
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Most Published Research Findings Are False—But a Little Replication Goes a Long Way |
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There is increasing concern that most current published research findings are false. The
probability that a research claim is true may depend on study power and bias, the number of …

Using Evidence to Combat Overdiagnosis and Overtreatment: Evaluating Treatments, Tests,
and Disease Definitions in the Time of Too Much | PLOS Medicine Skip to main content …

Observational Research, Randomised Trials, and Two Views of Medical Science | PLOS
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Doing New Research? Don't Forget the Old | PLOS Medicine Skip to main content
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Setting priorities for research should be conducted in order to make the most efficient use of
scarce resources. Yet the uptake in practice of such methods by researchers and …

Required reading in many medical and healthcare institutions, How to Read a Paper is a
clear and wide-ranging introduction to evidence-based medicine and healthcare, helping …

When judging the benefits and harms of health care and predicting patient prognosis,
clinicians, researchers, and others must consider many types of evidence. Medical research …

In the past 50 years we have made substantial progress in understanding the biology of
disease and in devising new ways to prevent or treat it. However, there has been a …