Mitochondrial DNA mutations transmitted maternally within the oocyte cytoplasm often cause
life-threatening disorders. Here we explore the use of nuclear genome transfer between …

Mitochondria are found in all eukaryotic cells and contain their own genome (mitochondrial
DNA or mtDNA). Unlike the nuclear genome, which is derived from both the egg and sperm …

Mutations in mitochondrial DNA (mtDNA) are associated with severe human diseases and
are maternally inherited through the egg's cytoplasm. Here we investigated the feasibility of …

Maternally inherited mitochondrial (mt) DNA mutations can cause fatal or severely
debilitating syndromes in children,,, with disease severity dependent on the specific gene …

Mitochondrial DNA (mtDNA) mutations are maternally inherited and are associated with a
broad range of debilitating and fatal diseases. Reproductive technologies designed to …

Mutations in mitochondrial DNA (mtDNA) are a common cause of genetic disease.
Pathogenic mutations in mtDNA are detected in approximately 1 in 250 live births,, and at …

Replacement of mitochondria through nuclear transfer between oocytes of two different
women has emerged recently as a strategy for preventing inheritance of mtDNA diseases …

Mitochondrial DNA is maternally inherited, and pathogenic mutations cause a range of life-
limiting conditions. Recent studies indicate that transmission of pathogenic mutations may …

Although mitochondrial DNA (mtDNA) is prone to mutation and few mtDNA repair
mechanisms exist, crippling mitochondrial mutations are exceedingly rare. Recent studies …

Mutations in mitochondrial DNA (mtDNA) are maternally inherited and can cause fatal or
debilitating mitochondrial disorders. The severity of clinical symptoms is often associated …