Apolipoprotein E (APOE) is the major cholesterol carrier in the brain, affecting various
normal cellular processes including neuronal growth, repair and remodeling of membranes …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
extracellular amyloid β (Aβ) and intraneuronal tau protein aggregations. One risk factor for …

Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …

Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …

One of the primary genetic risk factors for Alzheimer's disease (AD) is the presence of the Ɛ4
allele of apolipoprotein E (APOE). APOE is a polymorphic lipoprotein that is a major …

Alzheimer's disease (AD) is the most common form of dementia in individuals over the age
of 65 years. The most prevalent genetic risk factor for AD is the ε4 allele of apolipoprotein E …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder that causes
progressive cognitive decline. The majority of AD cases are sporadic and late-onset (> 65 …

The APOE gene is the strongest genetic risk factor for Alzheimer's disease (AD) with the ε4
allele increasing the risk by 2-4 folds compared to the most common ε3 allele [1]. The high …

Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons
in the central nervous system. APOE-dependent alterations of the endocytic pathway can …

Human apolipoprotein (APO) E has three common isoforms that differentially affect lipid and
neuronal homeostasis. APOE4, the major known genetic risk factor for Alzheimer's disease …