Myofibroblasts have characteristics of fibroblasts and smooth muscle cells: they produce
extracellular matrix and are able to contract. In so doing, they can contribute to tissue …

The importance of cardiac fibroblasts in the regulation of myocardial remodelling following
myocardial infarction (MI) is becoming increasingly recognised. Studies over the last few …

Myofibroblasts are differentiated fibroblasts that hold a key role in wound healing and
remodeling following myocardial infarction (MI). A large repertoire of stimuli, such as …

Fibroblasts do not only serve as matrix-producing reparative cells, but exhibit a wide range
of functions in inflammatory and immune responses, angiogenesis and neoplasia. The adult …

Cardiac fibroblasts (CF) play a pivotal role in the repair and remodeling of the heart that
occur following myocardial infarction (MI). The transition through the inflammatory …

Ischemic cell death during a myocardial infarction leads to a multiphase reparative response
in which the damaged tissue is replaced with a fibrotic scar produced by fibroblasts and …

Fibroblasts are the predominant cell type in the cardiac interstitium. As the main matrix-
producing cells in the adult mammalian heart, fibroblasts maintain the integrity of the …

The adult mammalian heart contains abundant interstitial and perivascular fibroblasts that
expand following injury and play a reparative role but also contribute to maladaptive fibrotic …

The syncytium of cardiomyocytes in the heart is tethered within a matrix composed
principally of type I fibrillar collagen. The matrix has diverse mechanical functions that …

Cardiac fibrosis is a substantial problem in managing multiple forms of heart disease.
Fibrosis results from an unrestrained tissue repair process orchestrated predominantly by …