Background Wound healing is impaired in diabetes mellitus, but the mechanisms involved in
this process are virtually unknown. Proteins belonging to the insulin signaling pathway …

Insulin signaling defects could lead to insulin resistance in insulin target organs: typically, in
the muscler, liver, and adipose tissue. We have observed that insulin accelerated diabetic …

Background. Diabetes is a condition known even in its early stages to impair the normal
course of wound healing, thus leading to chronic wounds. The role of insulin in the …

Abstract Diabetic foot ulcers affect 15–20% of all diabetic patients and remain an important
challenge since the available therapies have limited efficacy and some of the novel …

Wound healing is a complex biological process that repairs damaged tissues and restores
skin integrity. Insulin, a potent factor of wound healing, has been reported for nearly a …

Inflammation, the initiating stage of wound healing, is characterized by increased
endothelial permeability, infiltration of inflammatory cells, and secretion of numerous growth …

Background Regenerative wound repair is a goal of modern medicine. This is important not
only for the local repair but also for its beneficial effect to systemic physiological processes …

Besides regulating glucose levels, insulin has been reported to participate actively in many
other functions, including modulating inflammatory reactions. In this study we investigated …

Skin is a dynamic and complex organ that relies on the interaction of different cell types,
biomacromolecules and signaling molecules. Injury triggers a cascade of events designed …

The healing process is complex in diabetic wounds, and the healing mechanism of burn
wounds is different from that of incisional or excisional wounds. Data from our previous study …