Multiple molecular pathways and cellular processes have been implicated in the
neurobiology of autism and other neurodevelopmental conditions. There is a current focus …

Over the last decade, there have been growing interest and important developments in the
understanding of the mechanisms involved in the pathophysiology of neurodevelopmental …

Autism spectrum disorders (ASD) are diagnosed on the basis of three behavioral features
namely deficits in social communication, absence or delay in language, and stereotypy. The …

Synaptic gene conditions, ie,“synaptopathies,” involve disruption to genes expressed at the
synapse and account for between 0.5 and 2% of autism cases. They provide a unique entry …

The SHANK family of proteins play critical structural and functional roles in the postsynaptic
density (PSD) at excitatory glutamatergic synapses. Through their multidomain structure they …

Autism spectrum disorder (ASD) encompasses a group of multifactorial neurodevelopmental
disorders characterized by impaired social communication, social interaction and repetitive …

Background Neurodevelopmental disorders such as autism spectrum disorder (ASD) may
be caused by alterations in genes encoding proteins that are involved in synapse formation …

SHANK3 mutations, including de novo deletions, have been associated with autism
spectrum disorders (ASD). However, the effects of SHANK3 loss of function on …

The neural substrates and pathophysiological mechanisms underlying the onset of cognitive
and motor deficits in autism spectrum disorders (ASDs) remain unclear. Mutations in ASD …

Autism spectrum disorder (ASD) refers to a large set of neurodevelopmental disorders,
which have in common both repetitive behavior and abnormalities in social interactions and …