Poor glycaemic control in type 1 diabetes is associated with elevated serum IGFBP‐1 levels
and reduced rather than elevated serum IGF‐I levels. Increasing age is accompanied by a …

Homeostatic mechanisms normally maintain the plasma glucose concentration within
narrow limits despite major fluctuations in supply and demand. There is increasing evidence …

The incidence of peripheral, cerebro-and cardiovascular disease (CVD) in patients with type
2 diabetes mellitus is approximately twice as high as in the non-diabetic population …

The IGF system is increasingly implicated in the development of cardiovascular disease. The
effects of circulating IGFs on the vasculature are largely modulated by IGFBPs, which control …

Patients with insulin resistance and type 2 diabetes have an excessive risk of cardiovascular
disease (CVD); this increased risk is not fully explained by traditional risk factors such as …

Summary objective and design It has been suggested that circulating free IGF‐I participates
in glucose homeostasis and that IGFBP‐1 reflects changes in insulin sensitivity. To study this …

The existing literature on serum insulin-like growth factor I (IGF-I) levels in insulin-dependent
diabetes mellitus (IDDM) is conflicting. Free IGF-I may have greater physiological and …

Recently, a method to measure free insulin-like growth factor-I (IGF-I) levels has been
developed. Free IGF-I levels may have greater physiological and clinical relevance than …

Insulin-like growth factor-I (IGF-I) exerts insulin-like effects on fuel metabolism and
suppresses insulin secretion in normal subjects. Unlike insulin, circulating IGF-I is bound to …

Abstract IGF-I and-II levels are altered in patients with atherogenic lipid profiles and may
contribute to the development of macrovascular disease in NIDDM. We examined …