The heart requires fatty acids to maintain its activity. Various mechanisms regulate
myocardial fatty acid metabolism, such as energy production using fatty acids as fuel, for …

Fatty acids are the main substrates used by mitochondria to provide myocardial energy
under normal conditions. During heart remodeling, however, the fuel preference switches to …

There is a constant high demand for energy to sustain the continuous contractile activity of
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …

A fine balance between uptake, storage, and the use of high energy fuels, like lipids, is
crucial in the homeostasis of different metabolic tissues. Nowhere is this balance more …

Obesity and diabetes are major public health problems, and are linked to the development
of heart failure. Emerging data highlight the importance of alterations in cardiac energy …

To maintain its high energy demand the heart is equipped with a highly complex and
efficient enzymatic machinery that orchestrates ATP production using multiple energy …

J. Marın-Garcıa, MJ Goldenthal/Cardiovascular Research 54 (2002) 516–527 517 structural
and functional nature of the cardiac plasma and A key regulatory event in the uptake of fatty …

Cardiac ischemia and its consequences including heart failure, which itself has emerged as
the leading cause of morbidity and mortality in developed countries are accompanied by …

Despite recent advances in therapy, heart failure remains a major cause of mortality and
morbidity and is a growing healthcare burden worldwide. Alterations in myocardial energy …

Long chain fatty acids (LCFAs) provide 70-80% of the energy for cardiac contractile activity.
LCFAs are also essential for many other cellular functions, such as transcriptional regulation …