[HTML][HTML] PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer
PTX3 is an essential component of the humoral arm of innate immunity, playing a
nonredundant role in resistance against selected microbes and in the regulation of …
nonredundant role in resistance against selected microbes and in the regulation of …
PTX3, a humoral pattern recognition molecule, in innate immunity, tissue repair, and cancer
C Garlanda, B Bottazzi, E Magrini… - Physiological …, 2018 - journals.physiology.org
Innate immunity includes a cellular and a humoral arm. PTX3 is a fluid-phase pattern
recognition molecule conserved in evolution which acts as a key component of humoral …
recognition molecule conserved in evolution which acts as a key component of humoral …
[HTML][HTML] The dual complexity of PTX3 in health and disease: a balancing act?
E Magrini, A Mantovani, C Garlanda - Trends in molecular medicine, 2016 - cell.com
The humoral arm of innate immunity is complex and includes various molecules that serve
as markers of inflammation with complementary characteristics, such as the short pentraxins …
as markers of inflammation with complementary characteristics, such as the short pentraxins …
The long pentraxin PTX3 at the crossroads between innate immunity and tissue remodelling
Innate immunity represents the first line of defence against pathogens and plays key roles in
the activation and orientation of the adaptive immune response. The innate immune system …
the activation and orientation of the adaptive immune response. The innate immune system …
[HTML][HTML] PTP1B and TC-PTP: regulators of transformation and tumorigenesis
Abstract PTP1B and T cell PTP (TC-PTP) are protein tyrosine phosphatases (PTPs) that
share high sequence and structural homology yet play distinct physiological roles. While …
share high sequence and structural homology yet play distinct physiological roles. While …
[HTML][HTML] The long pentraxin PTX3 as a link between innate immunity, tissue remodeling, and cancer
A Doni, M Stravalaci, A Inforzato, E Magrini… - Frontiers in …, 2019 - frontiersin.org
The innate immune system comprises a cellular and a humoral arm. Humoral pattern
recognition molecules include complement components, collectins, ficolins, and pentraxins …
recognition molecules include complement components, collectins, ficolins, and pentraxins …
The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells, and edits the cross-presentation of self, viral, and tumor antigens
P Baruah, A Propato, IE Dumitriu, P Rovere-Querini… - Blood, 2006 - ashpublications.org
Pentraxins are soluble pattern recognition receptors with a dual role: protection against
extracellular microbes and autoimmunity. The mechanisms by which they accomplish these …
extracellular microbes and autoimmunity. The mechanisms by which they accomplish these …
[HTML][HTML] A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity
The inhibition of protein tyrosine phosphatases 1B (PTP1B) and N2 (PTPN2) has emerged
as an exciting approach for bolstering T cell anti-tumor immunity. ABBV-CLS-484 is a …
as an exciting approach for bolstering T cell anti-tumor immunity. ABBV-CLS-484 is a …
Long pentraxin 3: A novel multifaceted player in cancer
Since its discovery in 1992, long pentraxin 3 (PTX3) has been characterized as soluble
patter recognition receptor, a key player of the innate immunity arm with non-redundant …
patter recognition receptor, a key player of the innate immunity arm with non-redundant …
PTPN 2 phosphatase deletion in T cells promotes anti‐tumour immunity and CAR T‐cell efficacy in solid tumours
Although adoptive T‐cell therapy has shown remarkable clinical efficacy in haematological
malignancies, its success in combating solid tumours has been limited. Here, we report that …
malignancies, its success in combating solid tumours has been limited. Here, we report that …