Background Heart failure due to myocardial infarction (MI) involves fibrosis driven by
epicardium‐derived cells (EPDCs) and cardiac fibroblasts, but strategies to inhibit and …

Aims Myocardial fibrosis is associated with profound changes in ventricular architecture and
geometry, resulting in diminished cardiac function. There is currently no information on the …

Delta like non-canonical Notch ligand 1 (DLK1), as a member of epidermal growth factor-like
family, plays a critical role in somatic growth, tissue development and possibly tissue …

Delta like non-canonical Notch ligand 1 (Dlk1) is an imprinted gene, mainly known for its
involvement in adipogenesis, although it has been associated with many other stem …

Aims Notch1 signalling in the heart is mainly activated via expression of Jagged1 on the
surface of cardiomyocytes. Notch controls cardiomyocyte proliferation and differentiation in …

In dilated cardiomyopathy (DCM), adverse myocardial remodeling is essential, potentially
involving Notch signaling. We hypothesized that secreted Notch ligands would be …

Aims The epidermal growth factor-like protein Delta-like 1 (DLK1) regulates multiple
differentiation processes. It resembles NOTCH ligands structurally and is considered a non …

Cardiac fibrosis is a common pathological process in multiple cardiovascular diseases,
including myocardial infarction (MI). Abnormal cardiac fibroblast (CF) activity is a key event …

The Notch signalling pathway is pivotal in normal vascular development and post-natal
angiogenesis. Cumulative evidence supports the involvement of three canonical Notch …

Transforming growth factor-β1 signaling pathways are known to involve in the development
of post-infarction fibrosis, a process characterized by the aberrant activation, proliferation …