Objective Skeletal muscle insulin signaling is a major determinant of muscle growth and
glucose homeostasis. Protein kinase B/Akt plays a prominent role in mediating many of the …

The phosphoinositide 3-kinase/Akt pathway is thought to be essential for normal insulin
action and glucose metabolism in skeletal muscle and has been shown to be dysregulated …

Aims/hypothesis The serine/threonine kinase Akt/protein kinase B (PKB) is required for the
metabolic actions of insulin. Controversial data have been reported regarding Akt defective …

Recent evidence has shown that activation of phosphatidyinositol-3-kinase (PI3K) and Akt,
necessary for insulin stimulation of glucose transport, is impaired in insulin resistance. It is …

The serine/threonine kinase Akt (PKB/Rac) has been implicated as playing a role in the
insulin-signaling pathway to glucose transport. Little is known regarding the regulation of Akt …

Aims/hypothesis Muscle insulin resistance, one of the earliest defects associated with type 2
diabetes, involves changes in the phosphoinositide 3-kinase/Akt network. The relative …

Brief calorie restriction (CR; 20 days of 60% of ad libitum [AL] intake) improves insulin-
stimulated glucose transport, concomitant with enhanced phosphorylation of Akt2. The …

To determine whether the serine/threonine kinase Akt (also known as protein kinase B) is
activated in vivo by insulin administration in humans, and whether impaired activation of Akt …

The Akt/protein kinase B is critical regulator of cellular homeostasis with diminished Akt
activity being associated with dysregulation of cellular metabolism and cell death while Akt …

Activation of AMP-activated protein kinase (AMPK) by exercise induces several cellular
processes in muscle. Exercise activation of AMPK is unaffected in lean (BMI∼ 25 kg/m2) …