The mechanisms that specify and stabilize cell subtypes remain poorly understood. Here,
we identify two major subtypes of pancreatic β cells based on histone mark heterogeneity (β …

Insulin-secreting β cells and glucagon-secreting α cells maintain physiological blood
glucose levels, and their malfunction drives diabetes development. Using ChIP sequencing …

Pancreatic β-cells perform glucose-stimulated insulin secretion, a process at the center of
type 2 diabetes etiology. Efforts to understand how β-cells behave in healthy and stressful …

Broad heterogeneity in pancreatic β-cell function and morphology has been widely reported.
However, determining which components of this cellular heterogeneity serve a diabetes …

Objective Although glucagon-secreting α-cells and insulin-secreting β-cells have opposing
functions in regulating plasma glucose levels, the two cell types share a common …

The pancreatic beta cell functions as a key regulator of blood glucose levels by integrating a
variety of signals in response to changing metabolic demands. Variations in beta cell identity …

Diabetes, a metabolic disease with multiple causes characterized by high blood sugar, has
become a public health problem. Hyperglycaemia is caused by deficiencies in insulin …

EndoC-βH1 is emerging as a critical human β cell model to study the genetic and
environmental etiologies of β cell (dys) function and diabetes. Comprehensive knowledge of …

Beta cells are primarily defined by their ability to produce insulin and secrete it in response
to appropriate stimuli. It has been known for some time, however, that beta cells are not …

Type 2 diabetes (T2D) is a growing health problem worldwide. While peripheral insulin
resistance is common during obesity and aging in both animals and people, progression to …