Cellular and molecular actions of methylene blue in the nervous system
Methylene Blue (MB), following its introduction to biology in the 19th century by Ehrlich, has
found uses in various areas of medicine and biology. At present, MB is the first line of …
found uses in various areas of medicine and biology. At present, MB is the first line of …
Methylene blue and Alzheimer's disease
The relationship between methylene blue (MB) and Alzheimer's disease (AD) has recently
attracted increasing scientific attention since it has been suggested that MB may slow down …
attracted increasing scientific attention since it has been suggested that MB may slow down …
Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue
JC Rojas, AK Bruchey, F Gonzalez-Lima - Progress in neurobiology, 2012 - Elsevier
This paper provides the first review of the memory-enhancing and neuroprotective metabolic
mechanisms of action of methylene blue in vivo. These mechanisms have important …
mechanisms of action of methylene blue in vivo. These mechanisms have important …
Methylene blue-a therapeutic dye for all seasons?
M Wainwright, KB Crossley - Journal of chemotherapy, 2002 - Taylor & Francis
Since it was first synthesised in 1876, Methylene Blue (MB) has found uses in many different
areas of clinical medicine, ranging from dementia to cancer chemotherapy. In addition, MB …
areas of clinical medicine, ranging from dementia to cancer chemotherapy. In addition, MB …
From mitochondrial function to neuroprotection—an emerging role for methylene blue
Methylene blue (MB) is a well-established drug with a long history of use, owing to its
diverse range of use and its minimal side effect profile. MB has been used classically for the …
diverse range of use and its minimal side effect profile. MB has been used classically for the …
Azure B, a metabolite of methylene blue, is a high-potency, reversible inhibitor of monoamine oxidase
Methylene blue (MB) has been shown to act at multiple cellular and molecular targets and
as a result possesses diverse medical applications. Among these is a high potency …
as a result possesses diverse medical applications. Among these is a high potency …
Methylene blue reduces Aβ levels and rescues early cognitive deficit by increasing proteasome activity
Promising results have emerged from a phase II clinical trial testing methylene blue (MB) as
a potential therapeutic for Alzheimer disease (AD), where improvements in cognitive …
a potential therapeutic for Alzheimer disease (AD), where improvements in cognitive …
Protective role of methylene blue in Alzheimer's disease via mitochondria and cytochrome c oxidase
H Atamna, R Kumar - Journal of Alzheimer's Disease, 2010 - content.iospress.com
The key cytopathologies in the brains of Alzheimer's disease (AD) patients include
mitochondrial dysfunction and energy hypometabolism, which are likely caused by the …
mitochondrial dysfunction and energy hypometabolism, which are likely caused by the …
Methylene blue provides behavioral and metabolic neuroprotection against optic neuropathy
JC Rojas, JM John, J Lee, F Gonzalez-Lima - Neurotoxicity research, 2009 - Springer
Methylene blue (MB) is a diaminophenothiazine with potent antioxidant and unique redox
properties that prevent morphologic degenerative changes in the mouse retina induced by …
properties that prevent morphologic degenerative changes in the mouse retina induced by …
Methylene blue improves brain oxidative metabolism and memory retention in rats
NL Callaway, PD Riha, AK Bruchey, Z Munshi… - Pharmacology …, 2004 - Elsevier
Methylene blue (MB) increases mitochondrial oxygen consumption and restores memory
retention in rats metabolically impaired by inhibition of cytochrome c oxidase. This study …
retention in rats metabolically impaired by inhibition of cytochrome c oxidase. This study …
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