Therapeutic targeting of the tumor microenvironment
L Bejarano, MJC Jordāo, JA Joyce - Cancer discovery, 2021 - AACR
Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a
promising approach for cancer treatment in recent years due to the critical roles of the TME …
promising approach for cancer treatment in recent years due to the critical roles of the TME …
[HTML][HTML] New horizons in tumor microenvironment biology: challenges and opportunities
The tumor microenvironment (TME) is being increasingly recognized as a key factor in
multiple stages of disease progression, particularly local resistance, immune-escaping, and …
multiple stages of disease progression, particularly local resistance, immune-escaping, and …
[HTML][HTML] Targeting the tumor microenvironment: Potential strategy for cancer therapeutics
Q Babar, A Saeed, TA Tabish, M Sarwar… - Biochimica et Biophysica …, 2023 - Elsevier
Cellular and stromal components including tumor cells, immune cells, mesenchymal cells,
cancer-linked fibroblasts, and extracellular matrix, constituent tumor microenvironment …
cancer-linked fibroblasts, and extracellular matrix, constituent tumor microenvironment …
[HTML][HTML] Role of the tumor microenvironment in cancer hallmarks and targeted therapy
R Naser, I Fakhoury, A El-Fouani… - International …, 2022 - spandidos-publications.com
Genetic alterations drive tumor onset and progression. However, the cross-talk between
tumor cells and the benign components of the surrounding stroma can also promote the …
tumor cells and the benign components of the surrounding stroma can also promote the …
Tumor microenvironment: Interactions and therapy
Tumor microenvironment (TME) is a host for a complex network of heterogeneous stromal
cells with overlapping or opposing functions depending on the dominant signals within this …
cells with overlapping or opposing functions depending on the dominant signals within this …
Strategies targeting tumor immune and stromal microenvironment and their clinical relevance
The critical role of tumor microenvironment (TME) in tumor initiation and development has
been well-recognized after more than a century of studies. Numerous therapeutic …
been well-recognized after more than a century of studies. Numerous therapeutic …
[HTML][HTML] Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy
JM Pitt, A Marabelle, A Eggermont, JC Soria… - Annals of …, 2016 - Elsevier
The tumor microenvironment (TME) is an integral part of cancer. Recognition of the essential
nature of the TME in cancer evolution has led to a shift from a tumor cell-centered view of …
nature of the TME in cancer evolution has led to a shift from a tumor cell-centered view of …
Improving cancer therapies by targeting the physical and chemical hallmarks of the tumor microenvironment
Tumors are highly heterogeneous at the patient, tissue, cellular, and molecular levels. This
multi-scale heterogeneity poses significant challenges for effective therapies, which ideally …
multi-scale heterogeneity poses significant challenges for effective therapies, which ideally …
Targeting the tumor microenvironment: from understanding pathways to effective clinical trials
H Fang, YA DeClerck - Cancer research, 2013 - AACR
It is clear that tumor cells do not act alone but in close interaction with the extracellular matrix
and with stromal cells in the tumor microenvironment (TME). As our understanding of tumor …
and with stromal cells in the tumor microenvironment (TME). As our understanding of tumor …
Targeting the microenvironment in solid tumors
Tumorigenesis is a complex and dynamic process involving different cellular and non-
cellular elements composed of tumor microenvironment (TME). The interaction of TME with …
cellular elements composed of tumor microenvironment (TME). The interaction of TME with …