Two‐Pronged Intracellular Co‐Delivery of Antigen and Adjuvant for Synergistic Cancer Immunotherapy

J Meng, P Zhang, Q Chen, Z Wang, Y Gu… - Advanced …, 2022 - Wiley Online Library
Nanovaccines have emerged as promising alternatives or complements to conventional
cancer treatments. Despite the progresses, specific co‐delivery of antigen and adjuvant to …

Targeted codelivery of an antigen and dual agonists by hybrid nanoparticles for enhanced cancer immunotherapy

L Zhang, S Wu, Y Qin, F Fan, Z Zhang, C Huang… - Nano …, 2019 - ACS Publications
Among approaches of current cancer immunotherapy, a dendritic cell (DC)-targeted vaccine
based on nanotechnology could be a promising way to efficiently induce potent immune …

Engineering ApoE3-incorporated biomimetic nanoparticle for efficient vaccine delivery to dendritic cells via macropinocytosis to enhance cancer immunotherapy

S Zhou, Y Huang, Y Chen, S Liu, M Xu, T Jiang… - Biomaterials, 2020 - Elsevier
Efficient delivery of vaccines to dendritic cells (DCs) is critical for inducing sufficient immune
response and realizing effective cancer immunotherapy. In the past decade, researchers …

Amplified cancer immunotherapy of a surface-engineered antigenic microparticle vaccine by synergistically modulating tumor microenvironment

H Zhao, B Zhao, L Wu, H Xiao, K Ding, C Zheng… - ACS …, 2019 - ACS Publications
Efficient cancer vaccines not only require the co-delivery of potent antigens and highly
immunostimulatory adjuvants to initiate robust tumor-specific host immune response but also …

A visible codelivery nanovaccine of antigen and adjuvant with self-carrier for cancer immunotherapy

X Dong, J Liang, A Yang, Z Qian… - ACS applied materials …, 2019 - ACS Publications
Codelivery nanovaccines of antigens and adjuvants have achieved positive therapy for
cancer immunotherapy. The insufficient immunogenicity of these vaccines leads to the …

Hybrid nanovaccine for the co-delivery of the mRNA antigen and adjuvant

J Yang, S Arya, P Lung, Q Lin, J Huang, Q Li - Nanoscale, 2019 - pubs.rsc.org
For efficient cancer vaccines, the antitumor function largely relies on cytotoxic T cells, whose
activation can be effectively induced via antigen-encoding mRNA, making mRNA-based …

Cancer cell membrane-coated adjuvant nanoparticles with mannose modification for effective anticancer vaccination

R Yang, J Xu, L Xu, X Sun, Q Chen, Y Zhao, R Peng… - ACS …, 2018 - ACS Publications
Tumor vaccines for cancer prevention and treatment have attracted tremendous interests in
the area of cancer immunotherapy in recent years. In this work, we present a strategy to …

Synergistic tumor immunological strategy by combining tumor nanovaccine with gene-mediated extracellular matrix scavenger

Y Hu, L Lin, J Chen, A Maruyama, H Tian, X Chen - Biomaterials, 2020 - Elsevier
The antitumor efficacy of tumor vaccines is often limited by weak T cell responses and poor
activated T cells infiltration. Herein, we reported a novel synergistic strategy to …

Orchestrated yolk–shell nanohybrids regulate macrophage polarization and dendritic cell maturation for oncotherapy with augmented antitumor immunity

X Zhao, K Guo, K Zhang, S Duan, M Chen… - Advanced …, 2022 - Wiley Online Library
The protumoral and immunosuppressive tumor microenvironments greatly limit the antitumor
immune responses of nanoparticles for cancer immunotherapy. Here, the intrinsic …

Engineering anti-cancer nanovaccine based on antigen cross-presentation

VU Warrier, AI Makandar, M Garg, G Sethi… - Bioscience …, 2019 - portlandpress.com
Dendritic cells (DCs) present exogenous antigens on major histocompatibility complex
(MHC) class I molecules, thereby activating CD8+ T cells, contributing to tumor elimination …